Plasmacytoid dendritic cell response to transcription factor E2-2
Summary:
Analysis of plasmocytoid dendritic cells (PDCs) heterozygous null for the transcription factor E2-2. Deletion of E2-2 blocked the development of PDCs but not of other lineages. Results provide insight into the role of E2-2 in the specification of the PDC lineage.
Cisse B, Caton ML, Lehner M, Maeda T et al. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell 2008 Oct 3;135(1):37-48. PMID: 18854153
