Methyltransferase Hypb deficiency effect on the yolk sac during development
Summary:
Analysis of yolk sacs from E9 and E10.5 embryos lacking Hypb, a histone H3 lysine 36-specific methytransferase. Hypb deficiency results in lethality at E10.5-E11.5 and severe vascular defects in the embryo, yolk sac, and placenta. Results provide insight into the function of Hypb in development.
Hu M, Sun XJ, Zhang YL, Kuang Y et al. Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A 2010 Feb 16;107(7):2956-61. PMID: 20133625
