Transcription factor SRF deletion effect on hematopoietic stem cells
Summary:
Analysis of hematopoietic LSK (Lin-Sca1+c-Kit+) cells invalidated for the serum response factor (SRF) gene. SRF regulates genes controlling cytoskeleton structures involved in cell spreading, adhesion and migration. Results provide insight into the role of SRF in hematopoietic stem cell homeostasis.
Ragu C, Elain G, Mylonas E, Ottolenghi C et al. The transcription factor Srf regulates hematopoietic stem cell adhesion. Blood 2010 Nov 25;116(22):4464-73. PMID: 20709909