WHO 2008-classified acute myeloid leukemia subgroups (Analysis II): bone marrow mononuclear cells
Summary:
Analysis of BMMCs from untreated patients with AML-MRC (AML with myelodysplasia-related changes) and from the combined group AML-NOS plus AML-MLD-sole on the basis of cytogenetics or a myelodysplastic syndrome (MDS) history. Results provide insight into the relevance of MLD for AML classification.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Miesner M, Haferlach C, Bacher U, Weiss T et al. Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not otherwise specified" (AML-NOS) or "AML with myelodysplasia-related changes" (AML-MRC). Blood 2010 Oct 14;116(15):2742-51. PMID: 20581309
