Inhibition of Notch signaling in T cell acute lymphoblastic leukemia cell lines
Summary:
Analysis of T-ALL cell lines treated with γ-secretase inhibitor (GSI) to block Notch signaling. Cell lines include parental cells and cells transduced with ICN (a GSI-independent form of activated Notch1) or with c-Myc (a downstream Notch1 target). Results provide insight into Notch1 role in T-ALL.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Medyouf H, Gusscott S, Wang H, Tseng JC et al. High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med 2011 Aug 29;208(9):1809-22. PMID: 21807868
