One-Twenty-Two-1 knockout effect on hematopoietic stem cells
Summary:
Analysis of Lin- Sca-1+ c-Kit+ (LSK) cells, which include the hematopoietic stem cell (HSC) population, sorted from bone marrow of Ott1 knockouts. HSCs lacking Ott1 are unable to maintain quiescence during proliferative stress. Results provide insight into the role of Ott1 in stress hematopoiesis.
Xiao N, Jani K, Morgan K, Okabe R et al. Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. Blood 2012 May 24;119(21):4898-907. PMID: 22490678
