Intestinal epithelium response to ursodeoxycholic acid
Summary:
Analysis of normal colon epithelium of C57BL/6J females fed a standard diet containing 0.4% ursodeoxycholic acid (UDCA). UDCA mitigates colon carcinogenesis in humans and in animal models. Results provide insight into the molecular mechanisms underlying the anticarcinogenic action of UDCA.
Krishna-Subramanian S, Hanski ML, Loddenkemper C, Choudhary B et al. UDCA slows down intestinal cell proliferation by inducing high and sustained ERK phosphorylation. Int J Cancer 2012 Jun 15;130(12):2771-82. PMID: 21805474
