Analysis of brain across 6 age groups of Npc1−/− Balb/c females with Niemann-Pick Type C (NPC) disease. NPC is a neurodegenerative, lysosomal disorder caused by Npc1 or Npc2 gene dysfunction. Results provide insight into the molecular mechanisms underlying NPC progression.
Alam MS, Getz M, Safeukui I, Yi S et al. Genomic expression analyses reveal lysosomal, innate immunity proteins, as disease correlates in murine models of a lysosomal storage disorder. PLoS One 2012;7(10):e48273. PMID: 23094108
