Mutated anaplastic lymphoma kinase-driven neuroblastoma model
Summary:
Analysis of neuroblastomas (NB) induced by mutated anaplastic lymphoma kinase (ALKF1174L), MYCN, or both oncogenes. ALK is a gene normally expressed in the developing nervous system. Results provide insight into the role of mutated ALK in tumorigenesis.
Heukamp LC, Thor T, Schramm A, De Preter K et al. Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. Sci Transl Med 2012 Jul 4;4(141):141ra91. PMID: 22764207