Mitochondrial protease Clpp knockout effect on various tissues
Summary:
Analysis of brain, testis, liver, and heart muscle from C57BL/6 animals deficient in mitochondrial protease Clpp. Loss of Clpp leads to infertility, hearing loss, and growth retardation. Results provide insight into the role of Clpp in growth and survival in a mammalian system.
Gispert S, Parganlija D, Klinkenberg M, Dröse S et al. Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors. Hum Mol Genet 2013 Dec 15;22(24):4871-87. PMID: 23851121
