Antidepressant fluoxetine effect on depression model: dorsal dentate gyrus
Summary:
Analysis of dorsal dentate gyrus from adults subjected to chronic corticosterone (CORT) to induce depression-like behaviors, followed by combined treatment of CORT and selective serotonin reuptake inhibitor fluoxetine. Results provide insight into the molecular basis of antidepressant resistance.
Samuels BA, Leonardo ED, Dranovsky A, Williams A et al. Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors. PLoS One 2014;9(1):e85136. PMID: 24465494
