Transcription factor Tcfap2c deficiency effect on primordial germ cells
Summary:
Analysis of embryonic stem cells (ESCs) depleted for transcription factor Tcfap2c and PGC-like cells (PGCLCs) derived from the Tcfap2c-deficient ESCs. TFAP2C is a member of the activator protein-2 (AP-2) family. Results provide insight into the role of TFAP2C in germ cell fate.
Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S et al. Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. PLoS One 2013;8(8):e71113. PMID: 23967156
