Small molecule GW8510 effect on pancreatic alpha cell
Summary:
Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Fomina-Yadlin D, Kubicek S, Vetere A, He KH et al. GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity. PLoS One 2012;7(1):e28808. PMID: 22242153
