Histone demethylase KDM3A-deficiency effect on estrogen-stimulated breast cancer cells in vitro
Summary:
Analysis of estrogen receptor (ER)-positive breast cancer cell line MCF-7 depleted for KDM3A (histone lysine demethylase 3A) then treated with estrogen. Histone lysine methylation is an important regulator of transcription. Results provide insight into role of KDM3A in ER signaling in breast cancer.
Wade MA, Jones D, Wilson L, Stockley J et al. The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer. Nucleic Acids Res 2015 Jan;43(1):196-207. PMID: 25488809
