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    acsm3 acyl-CoA synthetase medium chain family member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 100002035, updated on 2-Nov-2024

    Summary

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    Official Symbol
    acsm3provided by ZNC
    Official Full Name
    acyl-CoA synthetase medium chain family member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080220-22
    See related
    Ensembl:ENSDARG00000004880 AllianceGenome:ZFIN:ZDB-GENE-080220-22
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:172040; CH73-60L17.3
    Summary
    Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See acsm3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (44725548..44747301, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (44872552..44893849, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene YEATS domain containing 2 Neighboring gene MAP6 domain containing 1 Neighboring gene small nucleolar RNA U85 Neighboring gene non-SMC condensin I complex, subunit D2 Neighboring gene small nucleolar RNA U85

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fatty acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acyl-coenzyme A synthetase ACSM3, mitochondrial
    NP_001104706.1
    XP_021333930.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111236.1 → NP_001104706.1  acyl-coenzyme A synthetase ACSM3, mitochondrial

      See identical proteins and their annotated locations for NP_001104706.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155584
      UniProtKB/TrEMBL
      A0A8M1NFI5, A9JRA7
      Related
      ENSDARP00000041805.5, ENSDART00000041806.6
      Conserved Domains (2) summary
      COG0365
      Location:54 → 583
      Acs; Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]
      cl17068
      Location:57 → 586
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      44725548..44747301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478255.1 → XP_021333930.1  acyl-coenzyme A synthetase ACSM3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M9QIK8
      Conserved Domains (1) summary
      cl17068
      Location:12 → 521
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_011016166.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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