U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    klf5a Kruppel like factor 5a [ Danio rerio (zebrafish) ]

    Gene ID: 100006043, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    klf5aprovided by ZNC
    Official Full Name
    Kruppel like factor 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090312-167
    See related
    Ensembl:ENSDARG00000015506 AllianceGenome:ZFIN:ZDB-GENE-090312-167
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-222f1.2
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within digestive tract development. Is expressed in gut; gut epithelium; head; and pharyngeal arch. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See klf5a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (34596823..34612633, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (33864335..33880241, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene LIM domain 7b Neighboring gene Kruppel like factor 12a Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene GPALPP motifs containing 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Zeng L, et al. Dev Biol, 2012 Jul 15. PMID 22609551
    2. Characterization and phylogenetic analysis of Krüppel-like transcription factor (KLF) gene family in tree shrews (Tupaia belangeri chinensis). Shao M, et al. Oncotarget, 2017 Mar 7. PMID 28032601, Free PMC Article
    3. A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis. Kotkamp K, et al. Dev Biol, 2014 Jan 15. PMID 24211655
    4. Genome-wide analysis of the zebrafish Klf family identifies two genes important for erythroid maturation. Xue Y, et al. Dev Biol, 2015 Jul 15. PMID 26015096
    5. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Krueppel-like factor 5

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      34596823..34612633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001344880.9 → XP_001344916.5  Krueppel-like factor 5

      UniProtKB/TrEMBL
      A0A8M1PZV0, E9QG09
      Related
      ENSDARP00000012722.9, ENSDART00000004361.10
      Conserved Domains (3) summary
      COG5048
      Location:322 → 408
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 369
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:391 → 416
      zf-H2C2_2; Zinc-finger double domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394496.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      203998..218516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471217.2 → XP_021326892.1  Krueppel-like factor 5

      UniProtKB/TrEMBL
      A0A8M9P800
      Conserved Domains (3) summary
      COG5048
      Location:322 → 408
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 369
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:391 → 416
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools