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    trim59 tripartite motif containing 59 [ Danio rerio (zebrafish) ]

    Gene ID: 100006971, updated on 14-Nov-2024

    Summary

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    Official Symbol
    trim59provided by ZNC
    Official Full Name
    tripartite motif containing 59provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060724-2
    See related
    Ensembl:ENSDARG00000079238 AllianceGenome:ZFIN:ZDB-GENE-060724-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-196b13.7
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in nucleoplasm. Is expressed in brain; female organism; ovary; spleen; and testis. Orthologous to human TRIM59 (tripartite motif containing 59). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See trim59 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1574782..1584093, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1611855..1619182, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene karyopherin alpha 4 (importin alpha 3) Neighboring gene microRNA 15c Neighboring gene microRNA 16a Neighboring gene structural maintenance of chromosomes 4 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene nanor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic exposure to an aqueous coal dust extract results in gene expression alterations associated with the development and function of connective tissue and the hematological system, immunological and inflammatory disease, and cancer in zebrafish. Caballero-Gallardo K, et al. Metallomics, 2018 Mar 1. PMID 29485154
    2. Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish. Boudinot P, et al. PLoS One, 2011. PMID 21789205, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 59

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      1574782..1584093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291407.4 → XP_009289682.1  tripartite motif-containing protein 59 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ASD9, E7F136
      Related
      ENSDARP00000056771.4, ENSDART00000056772.6
      Conserved Domains (2) summary
      cd00162
      Location:28 → 82
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00643
      Location:111 → 153
      zf-B_box; B-box zinc finger

    2. XM_021466296.2 → XP_021321971.1  tripartite motif-containing protein 59 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PIB6
      Conserved Domains (3) summary
      TIGR03185
      Location:148 → 290
      DNA_S_dndD; DNA sulfur modification protein DndD
      pfam00643
      Location:119 → 161
      zf-B_box; B-box zinc finger
      cl17238
      Location:32 → 87
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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