gper1 G protein-coupled estrogen receptor 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: gper1provided by Xenbase
Official Full Name: G protein-coupled estrogen receptor 1provided by Xenbase
Primary source: Xenbase:XB-GENE-1006475
See related: Ensembl:ENSXETG00000021597 AllianceGenome:Xenbase:XB-GENE-1006475
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: cepr; gper; GPR30; dry12; feg-1; lergu; lygpr; cmkrl2; lergu2; gpcr-br
Summary: Predicted to enable nuclear estrogen receptor activity. Predicted to be involved in cellular response to estradiol stimulus and nuclear receptor-mediated steroid hormone signaling pathway. Predicted to act upstream of or within several processes, including G protein-coupled receptor signaling pathway; apoptotic process; and regulation of vasoconstriction. Predicted to be located in several cellular components, including cytoplasmic vesicle; postsynaptic density; and synaptic membrane. Predicted to be active in Golgi apparatus. Orthologous to human GPER1 (G protein-coupled estrogen receptor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	9	NC_030685.2 (28385747..28395627, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	9	NC_030685.1 (22522899..22532808, complement)

Chromosome 9 - NC_030685.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of estrogen-synthesizing enzyme aromatase and G protein-coupled estrogen receptor (GPER) proteins throughout early embryogenesis in the model organism, Silurana tropicalis, is demonstrated.
Title: Early expression of aromatase and the membrane estrogen receptor GPER in neuromasts reveals a role for estrogens in the development of the frog lateral line system.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables angiotensin type I receptor activity	IEA Inferred from Electronic Annotation more info
enables angiotensin type II receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estradiol stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendritic spine membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled estrogen receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114253.1 → NP_001107725.1 G-protein coupled estrogen receptor 1

See identical proteins and their annotated locations for NP_001107725.1

Status: PROVISIONAL

Source sequence(s)

BC158534

UniProtKB/TrEMBL

B0BMR5, F6XIL9

Related

ENSXETP00000046670.4, ENSXETT00000046670.5

Conserved Domains (1) summary

cd14989
Location:47 → 321

7tmA_GPER1; G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors