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    SLC12A1 solute carrier family 12 member 1 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100328575, updated on 2-Dec-2024

    Summary

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    Gene symbol
    SLC12A1
    Gene description
    solute carrier family 12 member 1
    See related
    Ensembl:ENSOCUG00000016508
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    BSC1; NKCC2
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See SLC12A1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 12 NC_091443.1 (70939890..71048177)
    RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 17 NC_067390.1 (25142063..25250289, complement)

    Chromosome 12 - NC_091443.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 5 Neighboring gene myelin expression factor 2 Neighboring gene cortexin 2 Neighboring gene uncharacterized LOC138844680 Neighboring gene deoxyuridine triphosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternatively spliced isoforms of the putative renal Na-K-Cl cotransporter are differentially distributed within the rabbit kidney. Payne JA, et al. Proc Natl Acad Sci U S A, 1994 May 10. PMID 7514306, Free PMC Article
    2. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. Gillen CM, et al. J Biol Chem, 1996 Jul 5. PMID 8663127
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables sodium:potassium:chloride symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 12 member 1
    Names
    Na-K-2Cl cotransporter 2
    bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
    bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
    kidney-specific Na-K-Cl symporter
    solute carrier family 12 (sodium/potassium/chloride transporter), member 1
    solute carrier family 12 (sodium/potassium/chloride transporters), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170971.1 → NP_001164442.1  solute carrier family 12 member 1

      See identical proteins and their annotated locations for NP_001164442.1

      Status: PROVISIONAL

      Source sequence(s)
      U07547
      UniProtKB/Swiss-Prot
      P55015
      UniProtKB/TrEMBL
      G1TBS5
      Related
      ENSOCUP00000014189.3, ENSOCUT00000016508.4
      Conserved Domains (3) summary
      TIGR00930
      Location:103 → 1099
      2a30; K-Cl cotransporter
      pfam03522
      Location:694 → 1099
      SLC12; Solute carrier family 12
      pfam08403
      Location:89 → 155
      AA_permease_N; Amino acid permease N-terminal

    RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mOryCun1.1

    Genomic

    1. NC_091443.1 Reference mOryCun1.1

      Range
      70939890..71048177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55015.1 GenPept UniProtKB/Swiss-Prot:P55015

    Gene LinkOut

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