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    Rprd2 regulation of nuclear pre-mRNA domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100364568, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rprd2provided by RGD
    Official Full Name
    regulation of nuclear pre-mRNA domain containing 2provided by RGD
    Primary source
    RGD:2320792
    See related
    EnsemblRapid:ENSRNOG00000054294 AllianceGenome:RGD:2320792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II C-terminal domain binding activity. Predicted to be part of transcription preinitiation complex. Orthologous to human RPRD2 (regulation of nuclear pre-mRNA domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 75.9), Adrenal (RPKM 66.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rprd2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186000375..186056943, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183311132..183367959, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (197882666..197937844, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial Neighboring gene transfer RNA proline (anticodon AGG) 87 Neighboring gene pre-mRNA processing factor 3 Neighboring gene mitochondrial ribosomal protein S21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Ni Z, et al. Transcription, 2011 Sep-Oct. PMID 22231121, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    regulation of nuclear pre-mRNA domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427343.1 → NP_001414272.1  regulation of nuclear pre-mRNA domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000092500.2, ENSRNOT00000100824.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186000375..186056943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281096.1 → XP_063137166.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X2

    2. XM_063281095.1 → XP_063137165.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AHR3
      Related
      ENSRNOP00000068661.3, ENSRNOT00000085404.3

    3. XM_008761344.4 → XP_008759566.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JTD1, A0A8I5ZS80
      Related
      ENSRNOP00000111227.1, ENSRNOT00000141383.1
      Conserved Domains (2) summary
      smart00582
      Location:27 → 145
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      pfam16566
      Location:193 → 311
      CREPT; Cell-cycle alteration and expression-elevated protein in tumour

    4. XM_063281097.1 → XP_063137167.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X5

    5. XM_039103792.2 → XP_038959720.1  regulation of nuclear pre-mRNA domain-containing protein 2 isoform X4

      Conserved Domains (3) summary
      PRK03918
      Location:142 → 318
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam05109
      Location:319 → 645
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd17001
      Location:27 → 146
      CID_RPRD2; CID (CTD-Interacting Domain) of Regulation of nuclear pre-mRNA domain-containing protein 2
    Nucleotide Protein Strain
    Heading Accession and Version

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