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    Rab37 RAB37, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100364984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab37provided by RGD
    Official Full Name
    RAB37, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:2319982
    See related
    EnsemblRapid:ENSRNOG00000059793 AllianceGenome:RGD:2319982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and secretory granule. Predicted to be active in Golgi apparatus and endosome. Orthologous to human RAB37 (RAB37, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 44.0), Spleen (RPKM 33.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab37 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100833240..100900950)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100334639..100401974)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103643841..103711830)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693477 Neighboring gene transfer RNA alanine (anticodon AGC) 73 Neighboring gene Cd300 molecule-like family member F Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37. Higashio H, et al. Sci Rep, 2016 Mar 2. PMID 26931073, Free PMC Article
    2. Rab37 is a novel mast cell specific GTPase localized to secretory granules. Masuda ES, et al. FEBS Lett, 2000 Mar 17. PMID 10722846
    3. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza L, et al. J Biol Chem, 2004 Nov 5. PMID 15308636
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAB37, member RAS oncogene family; ras-related protein Rab-37
    Names
    RAB37, member of RAS oncogene family
    rCG35079-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430326.1 → NP_001417255.1  RAB37, member RAS oncogene family isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6ALE4

    2. NM_001430327.1 → NP_001417256.1  RAB37, member RAS oncogene family isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HKK7, D4A0G7

    3. NM_001430328.1 → NP_001417257.1  RAB37, member RAS oncogene family isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AJ11, A6HKK4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      100833240..100900950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247775.5 → XP_006247837.1  ras-related protein Rab-37 isoform X2

      Related
      ENSRNOP00000092980.1, ENSRNOT00000120041.2
      Conserved Domains (2) summary
      smart00175
      Location:24 → 185
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:23 → 213
      Rab26; Rab GTPase family 26 (Rab26)

    2. XM_039087796.2 → XP_038943724.1  ras-related protein Rab-37 isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:31 → 163
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_008768408.4 → XP_008766630.1  ras-related protein Rab-37 isoform X1

      Related
      ENSRNOP00000071538.1, ENSRNOT00000086469.3
      Conserved Domains (2) summary
      smart00175
      Location:31 → 192
      RAB; Rab subfamily of small GTPases
      cd04112
      Location:31 → 220
      Rab26; Rab GTPase family 26 (Rab26)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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