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    ERVFRD-1 endogenous retrovirus group FRD member 1, envelope [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 100425316, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ERVFRD-1provided by VGNC
    Official Full Name
    endogenous retrovirus group FRD member 1, envelopeprovided by VGNC
    Primary source
    VGNC:VGNC:81068
    See related
    Ensembl:ENSMMUG00000043161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Summary
    Many different endogenous retrovirus families are expressed in normal placental tissue at high levels, suggesting that endogenous retroviruses are functionally important in reproduction. This gene is part of an endogenous retrovirus provirus that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Apr 2015]
    Orthologs
    human all
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    Genomic context

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    See ERVFRD-1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 4 NC_041757.1 (158900809..158910522)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 4 NC_027896.1 (11296384..11306082, complement)

    Chromosome 4 - NC_041757.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC114677708 Neighboring gene neural precursor cell expressed, developmentally down-regulated 9 Neighboring gene small integral membrane protein 13 Neighboring gene uncharacterized LOC106997790 Neighboring gene small nucleolar RNA U13 Neighboring gene ELOVL fatty acid elongase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of an envelope protein from the FRD family of human endogenous retroviruses (HERV-FRD) conferring infectivity and functional conservation among simians. Blaise S, et al. J Virol, 2004 Jan. PMID 14694139, Free PMC Article
    2. Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Blaise S, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14557543, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in syncytium formation by plasma membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    syncytin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307972.3 → NP_001294901.1  syncytin-2 precursor

      See identical proteins and their annotated locations for NP_001294901.1

      Status: REVIEWED

      Source sequence(s)
      QNVO02000337
      UniProtKB/TrEMBL
      A0A1D5R0I7
      Related
      ENSMMUP00000053820.1, ENSMMUT00000076978.2
      Conserved Domains (1) summary
      cd09851
      Location:380 → 456
      HTLV-1-like_HR1-HR2; heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of human T-cell leukemia virus type 1 (HTLV-1), and related domains

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041757.1 Reference Mmul_10 Primary Assembly

      Range
      158900809..158910522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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