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    arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100489192, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgef6provided by Xenbase
    Official Full Name
    Rac/Cdc42 guanine nucleotide exchange factor 6provided by Xenbase
    Primary source
    Xenbase:XB-GENE-949773
    See related
    Ensembl:ENSXETG00000017497 AllianceGenome:Xenbase:XB-GENE-949773
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    pixa; cool2; mrx46; cool-2; alphaPIX
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See arhgef6 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (69146096..69210372, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (48039907..48104251, complement)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene multiple tissue opsin Neighboring gene CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) Neighboring gene small nucleolar RNA SNORD61 Neighboring gene transmembrane 9 superfamily member 2 Neighboring gene RNA binding motif protein X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 6
    Names
    Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      69146096..69210372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012969588.3 → XP_012825042.2  rho guanine nucleotide exchange factor 6 isoform X2

      UniProtKB/TrEMBL
      A0A6I8QWY3, A0A6I8QY34
      Related
      ENSXETP00000076754.2, ENSXETT00000103507.2
      Conserved Domains (7) summary
      cd12060
      Location:163 → 220
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:243 → 420
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:452 → 549
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:578 → 685
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:688 → 774
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:115 → 161
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21265
      Location:1 → 117
      CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

    2. XM_031891573.1 → XP_031747433.1  rho guanine nucleotide exchange factor 6 isoform X1

      UniProtKB/TrEMBL
      A0A6I8Q766, A0A6I8QY34
      Related
      ENSXETP00000064375.2, ENSXETT00000068033.2
      Conserved Domains (7) summary
      cd12060
      Location:163 → 220
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:243 → 420
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:452 → 549
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:578 → 678
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:681 → 767
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:115 → 161
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cd21265
      Location:1 → 117
      CH_alphaPIX; calponin homology (CH) domain found in alpha-Pak Interactive eXchange factor

    3. XM_031891574.1 → XP_031747434.1  rho guanine nucleotide exchange factor 6 isoform X3

      UniProtKB/TrEMBL
      A0A6I8QY34, A0A8J1IPB5
      Related
      ENSXETP00000073242.2, ENSXETT00000071868.2
      Conserved Domains (7) summary
      cd12060
      Location:116 → 173
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:196 → 373
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:405 → 502
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:531 → 638
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:641 → 727
      betaPIX_CC; betaPIX coiled coil
      pfam16615
      Location:68 → 114
      RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
      cl00030
      Location:9 → 70
      CH_SF; calponin homology (CH) domain superfamily

    4. XM_012969589.3 → XP_012825043.2  rho guanine nucleotide exchange factor 6 isoform X4

      UniProtKB/TrEMBL
      A0A6I8QY34, A0A8J0SUG7
      Conserved Domains (5) summary
      cd12060
      Location:8 → 65
      SH3_alphaPIX; Src Homology 3 domain of alpha-Pak Interactive eXchange factor
      cd00160
      Location:88 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:297 → 394
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam16614
      Location:423 → 530
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
      pfam16523
      Location:533 → 619
      betaPIX_CC; betaPIX coiled coil
    Nucleotide Protein Strain
    Heading Accession and Version

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