trabd2a TraB domain containing 2A [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: trabd2aprovided by Xenbase
Official Full Name: TraB domain containing 2Aprovided by Xenbase
Primary source: Xenbase:XB-GENE-6050964
See related: Ensembl:ENSXETG00000013102 AllianceGenome:Xenbase:XB-GENE-6050964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: Tiki1; c2orf89
Summary: Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within Wnt signaling pathway; negative regulation of Wnt signaling pathway; and proteolysis. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human TRABD2A (TraB domain containing 2A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (113191921..113238299, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (101012950..101058988, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identifies, through functional cDNA screening, a transmembrane protein Tiki1 that is expressed specifically in the dorsal Spemann-Mangold Organizer and is required for anterior development during Xenopus embryogenesis. Tiki1 antagonizes Wnt function in embryos
Title: Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metalloprotease TIKI1

Names: TRAB domain-containing protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282491.1 → NP_001269420.1 metalloprotease TIKI1 precursor

Status: VALIDATED

Source sequence(s)

AL647003, BX735424, CR449693, CR567358, CR567359, CX439581, JQ653417

UniProtKB/Swiss-Prot

F6PTN1, I6UYS9

UniProtKB/TrEMBL

A0A044PYE0

Related

ENSXETP00000028687.4, ENSXETT00000028687.5

Conserved Domains (1) summary

cd14789
Location:44 → 350

Tiki; Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

113191921..113238299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_031896758.1 → XP_031752618.1 metalloprotease TIKI1 isoform X1

UniProtKB/Swiss-Prot

F6PTN1, I6UYS9

UniProtKB/TrEMBL

A0A8J1J428

Conserved Domains (1) summary

cd14789
Location:68 → 374

Tiki; Tiki homology domain antagonizes Wnt function via cleavage of amino-terminal residues