U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    neu3 sialidase 3 (membrane sialidase) gene 1 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100496715, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    neu3provided by Xenbase
    Official Full Name
    sialidase 3 (membrane sialidase) gene 1provided by Xenbase
    Primary source
    Xenbase:XB-GENE-996645
    See related
    Ensembl:ENSXETG00000003807 AllianceGenome:Xenbase:XB-GENE-996645
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    sial3; neu3.1
    Summary
    Predicted to enable exo-alpha-sialidase activity. Predicted to be involved in ganglioside catabolic process and oligosaccharide catabolic process. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in lysosome and membrane. Orthologous to human NEU3 (neuraminidase 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See neu3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (174627181..174636094)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683489.1 (57036..60967, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene proteasomal ATPase-associated factor 1-like Neighboring gene gastrula zinc finger protein XlCGF48.2 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC116408635 Neighboring gene neuraminidase 3 (membrane sialidase) gene 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. New insights on the sialidase protein family revealed by a phylogenetic analysis in metazoa. Giacopuzzi E, et al. PLoS One, 2012. PMID 22952925, Free PMC Article
    2. Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loops. Giacopuzzi E, et al. BMC Biochem, 2011 Aug 23. PMID 21861893, Free PMC Article
    3. Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases. Monti E, et al. Genomics, 1999 Apr 1. PMID 10191093
    4. Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family. Monti E, et al. Genomics, 2004 Mar. PMID 14962670
    5. Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. Monti E, et al. Biochem J, 2000 Jul 1. PMID 10861246, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables exo-alpha-sialidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exo-alpha-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    sialidase-3
    Names
    neuraminidase 3
    sialidase NEU3.1
    NP_001297034.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310105.1 → NP_001297034.1  sialidase-3

      See identical proteins and their annotated locations for NP_001297034.1

      Status: PROVISIONAL

      Source sequence(s)
      BK008554
      UniProtKB/TrEMBL
      A0A1B8Y459, F6TPK8, K0PUS8
      Related
      ENSXETP00000008283.4, ENSXETT00000008283.5
      Conserved Domains (2) summary
      cd15482
      Location:10 → 386
      Sialidase_non-viral; Non-viral sialidases
      pfam13088
      Location:35 → 362
      BNR_2; BNR repeat-like domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      174627181..174636094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001126871.1: Suppressed sequence

      Description
      NM_001126871.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.