Atg14 autophagy related 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atg14provided by MGI
Official Full Name: autophagy related 14provided by MGI
Primary source: MGI:MGI:1261775
See related: Ensembl:ENSMUSG00000037526 AllianceGenome:MGI:1261775
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Atg14L; 4832427M01; D14Ertd114e; D14Ertd436e
Summary: Predicted to enable GTPase binding activity; phosphatidylinositol 3-kinase regulator activity; and protein-membrane adaptor activity. Involved in autophagy; cellular response to glucose starvation; and regulation of protein phosphorylation. Acts upstream of or within defense response to virus; innate immune response; and regulation of triglyceride metabolic process. Located in axoneme; mitochondria-associated endoplasmic reticulum membrane contact site; and phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in cerebral cortex. Orthologous to human ATG14 (autophagy related 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 4.7), CNS E18 (RPKM 4.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 24.6 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (47778350..47805891, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (47540893..47568434, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibiting miR-129-5p alleviates inflammation and modulates autophagy by targeting ATG14 in fungal keratitis.
Title: Inhibiting miR-129-5p alleviates inflammation and modulates autophagy by targeting ATG14 in fungal keratitis.
miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1.
Title: miR-25-3p promotes proliferation and inhibits autophagy of renal cells in polycystic kidney mice by regulating ATG14-Beclin 1.
Atg14(f/f) VC(+) intestinal epithelial cells demonstrated sensitivity to TNF-triggered apoptosis. Correspondingly, both TNF blocking antibody and genetic deletion of Tnfrsf1a/Tnfr1 rescued villus loss and cell death phenotype in Atg14(f/f) VC(+) mice.
Title: Atg14 protects the intestinal epithelium from TNF-triggered villus atrophy.
Taken together, autophagy induction via the PVT1-miR-152-ATG14 signaling pathway contributes to activation of hepatic stellate cells under hypoxia condition.
Title: Hypoxia induces the activation of hepatic stellate cells through the PVT1-miR-152-ATG14 signaling pathway.
miR199a-5p regulated the hepatic insulin sensitivity via ATG14-mediated autophagy.
Title: miR199a-5p inhibits hepatic insulin sensitivity via suppression of ATG14-mediated autophagy.
These results define a key molecular event for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1.
Title: The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity
Title: PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.
G-protein-coupled receptors, such as CXCR4, regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L .
Title: G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L.
These data reveal a key role for NRBF2 in the assembly of the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy induction.
Title: NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity.
Atg14 is a new target gene of FoxOs and the core clock machinery, and this gene plays an important role in hepatic lipid metabolism
Title: The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126115 (e-PCR)
- UniSTS:162827

RH126582 (e-PCR)
- UniSTS:209705

NoName (e-PCR)
- UniSTS:493361

RH127271 (e-PCR)
- UniSTS:167134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-membrane adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagosome membrane docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome membrane docking	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endosome to lysosome transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in post-transcriptional regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to lysosome	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mitochondrial depolarisation	IEA Inferred from Electronic Annotation more info
involved_in response to mitochondrial depolarisation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of omegasome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of omegasome membrane	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of omegasome membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extrinsic component of phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex, class III	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III	IDA Inferred from Direct Assay more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beclin 1-associated autophagy-related key regulator

Names: Atg14-like protein; VATG14 autophagy related 14 homolog; autophagy-related protein 14-like protein; barkor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.