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    Ube3c ubiquitin protein ligase E3C [ Mus musculus (house mouse) ]

    Gene ID: 100763, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ube3cprovided by MGI
    Official Full Name
    ubiquitin protein ligase E3Cprovided by MGI
    Primary source
    MGI:MGI:2140998
    See related
    Ensembl:ENSMUSG00000039000 AllianceGenome:MGI:2140998
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAUL; mKIAA0010
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human UBE3C (ubiquitin protein ligase E3C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 14.0), testis adult (RPKM 12.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ube3c in Genome Data Viewer
    Location:
    5 B1; 5 15.12 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (29774240..29881075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (29569242..29676077)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24538 Neighboring gene developmental pluripotency associated 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9635 Neighboring gene predicted gene, 42245 Neighboring gene predicted gene 43117

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein K29-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K29-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-protein ligase E3C
    Names
    HECT-type ubiquitin transferase E3C
    RTA-associated ubiquitin ligase
    NP_598668.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133907.3NP_598668.1  ubiquitin-protein ligase E3C

      See identical proteins and their annotated locations for NP_598668.1

      Status: PROVISIONAL

      Source sequence(s)
      AC104548, AC122782, AC169627
      Consensus CDS
      CCDS39042.1
      UniProtKB/Swiss-Prot
      Q0VB95, Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5
      Related
      ENSMUSP00000045998.5, ENSMUST00000049453.9
      Conserved Domains (2) summary
      smart00119
      Location:7471080
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:7231081
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      29774240..29881075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)