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    Mcm8 minichromosome maintenance 8 homologous recombination repair factor [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100772692, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Mcm8
    Gene description
    minichromosome maintenance 8 homologous recombination repair factor
    Locus tag
    I79_000449
    See related
    Ensembl:ENSCGRG00015010522
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Mcm8 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613587.1 (5556489..5609991, complement)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 6 NC_048599.1 (45696429..45750169, complement)

    NW_003613587.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene leucine rich repeat neuronal 4 Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene chromogranin B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA helicase MCM8
    Names
    Cardiolipin synthetase
    DNA replication licensing factor MCM8
    minichromosome maintenance complex component 8
    minichromosome maintenance deficient 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003613587.1 Reference CriGri_1.0 Primary Assembly

      Range
      5556489..5609991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007627413.4 → XP_007625603.1  DNA helicase MCM8 isoform X2

      Conserved Domains (4) summary
      cd00009
      Location:378 → 536
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG0558
      Location:758 → 948
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
      pfam00493
      Location:332 → 691
      MCM; MCM2/3/5 family
      pfam14551
      Location:98 → 166
      MCM_N; MCM N-terminal domain

    2. XM_007627355.4 → XP_007625545.1  DNA helicase MCM8 isoform X1

      Conserved Domains (4) summary
      cd00009
      Location:428 → 586
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG0558
      Location:808 → 998
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]
      pfam00493
      Location:382 → 741
      MCM; MCM2/3/5 family
      pfam14551
      Location:91 → 216
      MCM_N; MCM N-terminal domain

    3. XM_003495259.5 → XP_003495307.1  DNA helicase MCM8 isoform X3

      See identical proteins and their annotated locations for XP_003495307.1

      UniProtKB/TrEMBL
      A0A8C2MK71, G3GSC8
      Conserved Domains (3) summary
      cd00009
      Location:428 → 586
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG1241
      Location:155 → 830
      Mcm2; DNA replicative helicase MCM subunit Mcm2, Cdc46/Mcm family [Replication, recombination and repair]
      pfam14551
      Location:91 → 216
      MCM_N; MCM N-terminal domain

    RNA

    1. XR_003485339.2 RNA Sequence

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NC_048599.1 Alternate CriGri-PICRH-1.0

      Range
      45696429..45750169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027421701.2 → XP_027277502.1  DNA helicase MCM8 isoform X2

      UniProtKB/TrEMBL
      A0A9J7JS01

    2. XM_027421700.2 → XP_027277501.1  DNA helicase MCM8 isoform X1

      UniProtKB/TrEMBL
      A0A9J7G6M1

    3. XM_027421703.2 → XP_027277504.1  DNA helicase MCM8 isoform X3

      UniProtKB/TrEMBL
      A0A8C2MK71, A0A9J7G6M8
      Related
      ENSCGRP00015013719.2, ENSCGRT00015016802.2

    RNA

    1. XR_003486513.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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