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    Mtfr2 mitochondrial fission regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911069, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtfr2provided by RGD
    Official Full Name
    mitochondrial fission regulator 2provided by RGD
    Primary source
    RGD:6494892
    See related
    EnsemblRapid:ENSRNOG00000078862 AllianceGenome:RGD:6494892
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dufd1
    Summary
    Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be located in mitochondrion. Orthologous to human MTFR2 (mitochondrial fission regulator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 104.1), Spleen (RPKM 38.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtfr2 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16942814..16958218)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15123232..15138632)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15834779..15850424)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene BCL2-associated transcription factor 1 Neighboring gene phosphodiesterase 7B Neighboring gene uncharacterized LOC134484964 Neighboring gene uncharacterized LOC134484963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. Monticone M, et al. J Cell Physiol, 2010 Nov. PMID 20568109
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial fission regulator 2
    Names
    DUF729 domain containing 1
    protein FAM54A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290110.1 → NP_001277039.1  mitochondrial fission regulator 2

      See identical proteins and their annotated locations for NP_001277039.1

      Status: PROVISIONAL

      Source sequence(s)
      BC159435
      UniProtKB/Swiss-Prot
      B0K035
      Related
      ENSRNOP00000072258.1, ENSRNOT00000079069.3
      Conserved Domains (1) summary
      pfam05308
      Location:40 → 307
      Mito_fiss_reg; Mitochondrial fission regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16942814..16958218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284133.1 → XP_063140203.1  mitochondrial fission regulator 2 isoform X1

    2. XM_039103500.2 → XP_038959428.1  mitochondrial fission regulator 2 isoform X1

      Conserved Domains (1) summary
      pfam05308
      Location:1 → 129
      Mito_fiss_reg; Mitochondrial fission regulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0K035.1 GenPept UniProtKB/Swiss-Prot:B0K035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials