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    oaz1a ornithine decarboxylase antizyme 1a [ Takifugu rubripes (torafugu) ]

    Gene ID: 101069317, updated on 8-Mar-2024

    Summary

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    Gene symbol
    oaz1a
    Gene description
    ornithine decarboxylase antizyme 1a
    See related
    Ensembl:ENSTRUG00000017848
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Takifugu rubripes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu
    Also known as
    azs; oaz1
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This antizyme shares similarity with fish oaz1s/azs and vertebrate antizyme 1, which has broad tissue distribution and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Like vertebrate antizyme 1 mRNA, this mRNA also contains a potential in-frame translation initiation site. [provided by RefSeq, Apr 2015]
    Orthologs
    human zebrafish all
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    Genomic context

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    See oaz1a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current fTakRub1.2 (GCF_901000725.2) 20 NC_042304.1 (7206678..7209955, complement)
    101 previous assembly FUGU5 (GCF_000180615.1) 20 NC_018909.1 (5118996..5122259, complement)

    Chromosome 20 - NC_042304.1Genomic Context describing neighboring genes Neighboring gene oogenesis-related gene Neighboring gene uncharacterized LOC115247342 Neighboring gene PEAK family member 3 Neighboring gene anti-Mullerian hormone Neighboring gene DOT1-like histone H3K79 methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308228.2 → NP_001295157.1  ornithine decarboxylase antizyme 1

      Status: REVIEWED

      Source sequence(s)
      LR584236
      UniProtKB/TrEMBL
      H2V981
      Related
      ENSTRUP00000045771.2, ENSTRUT00000045925.3
      Conserved Domains (1) summary
      pfam02100
      Location:127 → 210
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: Takifugu rubripes Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fTakRub1.2 Primary Assembly

    Genomic

    1. NC_042304.1 Reference fTakRub1.2 Primary Assembly

      Range
      7206678..7209955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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