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    MARK2 microtubule affinity regulating kinase 2 [ Trichechus manatus latirostris (Florida manatee) ]

    Gene ID: 101356145, updated on 8-Mar-2024

    Summary

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    Gene symbol
    MARK2
    Gene description
    microtubule affinity regulating kinase 2
    See related
    EnsemblRapid:ENSTMLG00000010272
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Trichechus manatus latirostris (sub-species: latirostris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus
    Orthologs
    human mouse all
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    Genomic context

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    See MARK2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_01 current TriManLat1.0 (GCF_000243295.1) Unplaced Scaffold NW_004444049.1 (7218725..7279112, complement)

    NW_004444049.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene REST corepressor 2 Neighboring gene uncharacterized LOC111821879 Neighboring gene spindlin interactor and repressor of chromatin binding Neighboring gene zinc finger translocation associated

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004444049 Unplaced Scaffold Reference TriManLat1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tau-protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MARK2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000243295.1-RS_2024_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference TriManLat1.0 Primary Assembly

    Genomic

    1. NW_004444049.1 Reference TriManLat1.0 Primary Assembly

      Range
      7218725..7279112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004383809.1 → XP_004383866.1  serine/threonine-protein kinase MARK2 isoform X5

      UniProtKB/TrEMBL
      A0A2Y9E0E0
      Related
      ENSTMLP00000014515.1, ENSTMLT00000015575.1
      Conserved Domains (4) summary
      cd12201
      Location:611 → 709
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    2. XM_004383807.1 → XP_004383864.1  serine/threonine-protein kinase MARK2 isoform X3

      UniProtKB/TrEMBL
      A0A2Y9E057
      Related
      ENSTMLP00000014485.1, ENSTMLT00000015544.1
      Conserved Domains (4) summary
      cd12201
      Location:626 → 724
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    3. XM_004383808.1 → XP_004383865.1  serine/threonine-protein kinase MARK2 isoform X4

      UniProtKB/TrEMBL
      A0A2Y9DZA3
      Related
      ENSTMLP00000014504.1, ENSTMLT00000015564.1
      Conserved Domains (4) summary
      cd12201
      Location:621 → 719
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    4. XM_004383804.1 → XP_004383861.1  serine/threonine-protein kinase MARK2 isoform X1

      UniProtKB/TrEMBL
      A0A2Y9E0D5
      Related
      ENSTMLP00000014452.1, ENSTMLT00000015509.1
      Conserved Domains (4) summary
      cd12201
      Location:690 → 788
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    5. XM_004383806.1 → XP_004383863.1  serine/threonine-protein kinase MARK2 isoform X2

      UniProtKB/TrEMBL
      A0A2Y9DYP1
      Conserved Domains (4) summary
      cd12201
      Location:647 → 745
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:20 → 271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:289 → 330
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:19 → 271
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    6. XM_012557661.2 → XP_012413115.1  serine/threonine-protein kinase MARK2 isoform X6

      UniProtKB/TrEMBL
      A0A2Y9G1N7
      Conserved Domains (4) summary
      cd12201
      Location:689 → 787
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    7. XM_004383805.2 → XP_004383862.1  serine/threonine-protein kinase MARK2 isoform X7

      UniProtKB/TrEMBL
      A0A2Y9DYX8
      Related
      ENSTMLP00000014469.1, ENSTMLT00000015528.1
      Conserved Domains (4) summary
      cd12201
      Location:680 → 778
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:53 → 304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:322 → 363
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:52 → 304
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RNA

    1. XR_002825219.1 RNA Sequence

    2. XR_002825220.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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