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    Nr1h2 nuclear receptor subfamily 1 group H member 2 [ Heterocephalus glaber (naked mole-rat) ]

    Gene ID: 101700273, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Nr1h2
    Gene description
    nuclear receptor subfamily 1 group H member 2
    Locus tag
    GW7_15322
    See related
    Ensembl:ENSHGLG00000009407
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Heterocephalus glaber
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae; Heterocephalus
    Orthologs
    human mouse all
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    Genomic context

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    See Nr1h2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    102 current HetGla_female_1.0 (GCF_000247695.1) Unplaced Scaffold NW_004624832.1 (4136052..4141648, complement)

    NW_004624832.1Genomic Context describing neighboring genes Neighboring gene Spi-B transcription factor Neighboring gene DNA polymerase delta 1, catalytic subunit Neighboring gene napsin A aspartic peptidase Neighboring gene uncharacterized LOC101702516 Neighboring gene potassium voltage-gated channel subfamily C member 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004624832 Unplaced Scaffold Reference HetGla_female_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Kim EB, et al. Nature, 2011 Oct 12. PMID 21993625, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    oxysterols receptor LXR-beta
    Names
    Oxysterols receptor LXR-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Heterocephalus glaber Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HetGla_female_1.0 Primary Assembly

    Genomic

    1. NW_004624832.1 Reference HetGla_female_1.0 Primary Assembly

      Range
      4136052..4141648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021245810.1 → XP_021101469.1  oxysterols receptor LXR-beta isoform X1

      Conserved Domains (2) summary
      cd06954
      Location:264 → 500
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:117 → 209
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    2. XM_021245813.1 → XP_021101472.1  oxysterols receptor LXR-beta isoform X5

      Conserved Domains (2) summary
      cd06954
      Location:174 → 410
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:27 → 119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    3. XM_021245812.1 → XP_021101471.1  oxysterols receptor LXR-beta isoform X3

      Conserved Domains (2) summary
      cd06954
      Location:218 → 454
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:71 → 163
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    4. XM_004866827.3 → XP_004866884.1  oxysterols receptor LXR-beta isoform X2

      UniProtKB/TrEMBL
      A0A0N8ETG9
      Conserved Domains (2) summary
      cd06954
      Location:264 → 499
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:117 → 209
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    5. XM_021245815.1 → XP_021101474.1  oxysterols receptor LXR-beta isoform X6

      Conserved Domains (1) summary
      cd06954
      Location:119 → 354
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors

    6. XM_004866828.3 → XP_004866885.1  oxysterols receptor LXR-beta isoform X4

      See identical proteins and their annotated locations for XP_004866885.1

      UniProtKB/TrEMBL
      G5B8S5
      Related
      ENSHGLP00000013160.1, ENSHGLT00000013298.1
      Conserved Domains (2) summary
      cd06954
      Location:218 → 453
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:71 → 163
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    7. XM_021245814.1 → XP_021101473.1  oxysterols receptor LXR-beta isoform X5

      Conserved Domains (2) summary
      cd06954
      Location:174 → 410
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:27 → 119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    8. XM_021245811.1 → XP_021101470.1  oxysterols receptor LXR-beta isoform X1

      Conserved Domains (2) summary
      cd06954
      Location:264 → 500
      NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
      cl02596
      Location:117 → 209
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    Nucleotide Protein
    Heading Accession and Version

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