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    Stat1 signal transducer and activator of transcription 1 [ Mesocricetus auratus (golden hamster) ]

    Gene ID: 101827798, updated on 11-Apr-2024

    Summary

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    Gene symbol
    Stat1
    Gene description
    signal transducer and activator of transcription 1
    See related
    EnsemblRapid:ENSMAUG00000015184
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mesocricetus auratus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Mesocricetus
    Orthologs
    human mouse all
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    Genomic context

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    See Stat1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    103 current BCM_Maur_2.0 (GCF_017639785.1) Unplaced Scaffold NW_024429194.1 (58564640..58606890)
    102 previous assembly MesAur1.0 (GCF_000349665.1) Unplaced Scaffold NW_004801774.1 (2985367..3027713, complement)

    NW_024429194.1Genomic Context describing neighboring genes Neighboring gene myosin IB Neighboring gene U6atac minor spliceosomal RNA Neighboring gene signal transducer and activator of transcription 4 Neighboring gene transmembrane protein 209-like Neighboring gene glutaminase Neighboring gene uncharacterized LOC121142836 Neighboring gene uncharacterized LOC121142835

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication. Nishio M, et al. J Virol, 2005 Jul. PMID 15956600, Free PMC Article
    2. Reduced nitric oxide synthase 2 (NOS2) promoter activity in the Syrian hamster renders the animal functionally deficient in NOS2 activity and unable to control an intracellular pathogen. Perez LE, et al. J Immunol, 2006 May 1. PMID 16622021
    3. De novo assembly, annotation, and characterization of the whole brain transcriptome of male and female Syrian hamsters. McCann KE, et al. Sci Rep, 2017 Jan 10. PMID 28071753, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 1-alpha/beta
    Names
    STAT1 alpha
    STAT1 beta
    signal transducer and activator of transcription 1 alpha
    signal transducer and activator of transcription 1 beta
    signal transducer and activator of transcription 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281685.1 → NP_001268614.1  signal transducer and activator of transcription 1-alpha/beta

      See identical proteins and their annotated locations for NP_001268614.1

      Status: PROVISIONAL

      Source sequence(s)
      AB177397
      UniProtKB/TrEMBL
      Q1T7E9, Q4JGY3
      Related
      ENSMAUP00000015884.2, ENSMAUT00000019816.2
      Conserved Domains (4) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139 → 315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317 → 566
      STAT_bind; STAT protein, DNA binding domain

    RefSeqs of Annotated Genomes: Mesocricetus auratus Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference BCM_Maur_2.0 Primary Assembly

    Genomic

    1. NW_024429194.1 Reference BCM_Maur_2.0 Primary Assembly

      Range
      58564640..58606890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013123959.3 → XP_012979413.1  signal transducer and activator of transcription 1-alpha/beta isoform X1

      See identical proteins and their annotated locations for XP_012979413.1

      UniProtKB/TrEMBL
      Q4JGY3, Q4R4G1
      Related
      ENSMAUP00000046734.1, ENSMAUT00000059258.1
      Conserved Domains (5) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139 → 315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317 → 566
      STAT_bind; STAT protein, DNA binding domain
      pfam12162
      Location:715 → 739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    2. XM_021235559.2 → XP_021091218.1  signal transducer and activator of transcription 1-alpha/beta isoform X1

      UniProtKB/TrEMBL
      Q4JGY3, Q4R4G1
      Conserved Domains (5) summary
      cd10372
      Location:557 → 707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2 → 121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139 → 315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317 → 566
      STAT_bind; STAT protein, DNA binding domain
      pfam12162
      Location:715 → 739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    Nucleotide Protein
    Heading Accession and Version

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