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    LEP leptin [ Bubalus bubalis (water buffalo) ]

    Gene ID: 102401642, updated on 18-Dec-2024

    Summary

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    Gene symbol
    LEP
    Gene description
    leptin
    See related
    EnsemblRapid:ENSBALG00030033560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bubalus bubalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
    Also known as
    LP; OB; obese
    Orthologs
    human mouse all
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    Genomic context

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    See LEP in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    103 current NDDB_SH_1 (GCF_019923935.1) 8 NC_059164.1 (91971271..91988108)
    102 previous assembly NDDB_DH_1 (GCF_019923925.1) 8 NC_058350.1 (91132528..91149368)

    Chromosome 8 - NC_059164.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123334789 Neighboring gene uncharacterized LOC102402183 Neighboring gene RNA binding motif protein 28 Neighboring gene proline rich transmembrane protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LEP Gene Promotes Milk Fat Synthesis via the JAK2-STAT3 and mTOR Signaling Pathways in Buffalo Mammary Epithelial Cells. Gao R, et al. Animals (Basel), 2024 Aug 22. PMID 39199979, Free PMC Article
    2. Molecular cloning and analysis of the swamp and river buffalo leptin gene. Vallinoto M, et al. Anim Genet, 2004 Dec. PMID 15566470
    3. Partial cloning and localization of leptin and leptin receptor in the mammary gland of the Egyptian water buffalo. Sayed-Ahmed A, et al. Domest Anim Endocrinol, 2003 Oct. PMID 14550514
    4. De Novo Transcriptome Assembly of the Chinese Swamp Buffalo by RNA Sequencing and SSR Marker Discovery. Deng T, et al. PLoS One, 2016. PMID 26766209, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peptide hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of appetite by leptin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tyrosine phosphorylation of STAT protein IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leptin
    Names
    Obesity factor
    leptin protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290901.1 → NP_001277830.1  leptin precursor

      See identical proteins and their annotated locations for NP_001277830.1

      Status: PROVISIONAL

      Source sequence(s)
      EU541447
      UniProtKB/Swiss-Prot
      Q5J732
      UniProtKB/TrEMBL
      B2CPV3, G8BLB3
      Conserved Domains (1) summary
      pfam02024
      Location:26 → 167
      Leptin; Leptin

    RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NDDB_SH_1 Primary Assembly

    Genomic

    1. NC_059164.1 Reference NDDB_SH_1 Primary Assembly

      Range
      91971271..91988108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_044946370.2 → XP_044802305.1  leptin isoform X2

      UniProtKB/TrEMBL
      A0A0K2FR45

    2. XM_044946369.2 → XP_044802304.1  leptin isoform X1

      UniProtKB/TrEMBL
      A0A0K2FR45
      Related
      ENSBALP00030062234.1, ENSBALT00030093011.1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5J732.1 GenPept UniProtKB/Swiss-Prot:Q5J732

    Gene LinkOut

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