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    KMT2A lysine methyltransferase 2A [ Physeter catodon (sperm whale) ]

    Gene ID: 102981445, updated on 10-Mar-2024

    Summary

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    Gene symbol
    KMT2A
    Gene description
    lysine methyltransferase 2A
    See related
    Ensembl:ENSPCTG00005011949
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Physeter catodon
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Physeteridae; Physeter
    Orthologs
    human mouse all
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    Genomic context

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    See KMT2A in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2023_04 current ASM283717v5 (GCF_002837175.3) 16 NC_041229.1 (13998700..14075439, complement)
    102 previous assembly ASM283717v2 (GCF_002837175.2) 16 NC_041229.1 (13999394..14075439, complement)

    Chromosome 16 - NC_041229.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 25 Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene uncharacterized LOC102981171 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene ATP synthase membrane subunit g Neighboring gene ubiquitination factor E4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002837175.3-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM283717v5 Primary Assembly

    Genomic

    1. NC_041229.1 Reference ASM283717v5 Primary Assembly

      Range
      13998700..14075439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024131283.3 → XP_023987051.1  histone-lysine N-methyltransferase 2A isoform X4

      UniProtKB/TrEMBL
      A0A2Y9T7Z9
      Related
      ENSPCTP00005018196.1, ENSPCTT00005020051.1
      Conserved Domains (12) summary
      cd05493
      Location:1648 → 1778
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3669 → 3752
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3831 → 3951
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3953 → 3969
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1148 → 1195
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1434 → 1480
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1482 → 1531
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1569 → 1625
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1872 → 1984
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2025 → 2072
      FYRN; F/Y-rich N-terminus
      pfam10428
      Location:2101 → 2251
      SOG2; RAM signalling pathway protein
      cl27169
      Location:1241 → 1321
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    2. XM_024131282.3 → XP_023987050.1  histone-lysine N-methyltransferase 2A isoform X3

      UniProtKB/TrEMBL
      A0A2Y9TDY4
      Related
      ENSPCTP00005018153.1, ENSPCTT00005020005.1
      Conserved Domains (12) summary
      cd05493
      Location:1651 → 1781
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3672 → 3755
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3834 → 3954
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3956 → 3972
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1148 → 1195
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1434 → 1480
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1482 → 1531
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1569 → 1628
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1875 → 1987
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2028 → 2075
      FYRN; F/Y-rich N-terminus
      pfam10428
      Location:2104 → 2254
      SOG2; RAM signalling pathway protein
      cl27169
      Location:1241 → 1321
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    3. XM_055078729.1 → XP_054934704.1  histone-lysine N-methyltransferase 2A isoform X2

      UniProtKB/TrEMBL
      A0A9W2W601

    4. XM_024131281.3 → XP_023987049.1  histone-lysine N-methyltransferase 2A isoform X1

      UniProtKB/TrEMBL
      A0A2Y9TFU1
      Conserved Domains (12) summary
      cd05493
      Location:1684 → 1814
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3705 → 3788
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:3867 → 3987
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3989 → 4005
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam02008
      Location:1181 → 1228
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:1467 → 1513
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1515 → 1564
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1602 → 1661
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1908 → 2020
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:2061 → 2108
      FYRN; F/Y-rich N-terminus
      pfam10428
      Location:2137 → 2287
      SOG2; RAM signalling pathway protein
      cl27169
      Location:1274 → 1354
      ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

    5. XM_024131285.3 → XP_023987053.2  histone-lysine N-methyltransferase 2A isoform X6

      UniProtKB/TrEMBL
      A0A2Y9T9Z2

    6. XM_055078730.1 → XP_054934705.1  histone-lysine N-methyltransferase 2A isoform X5

      UniProtKB/TrEMBL
      A0A9W2W721

    7. XM_007124162.4 → XP_007124224.1  histone-lysine N-methyltransferase 2A isoform X7

      UniProtKB/TrEMBL
      A0A2Y9FJC5
      Conserved Domains (11) summary
      cd05493
      Location:780 → 910
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:2801 → 2884
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:2963 → 3083
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:3085 → 3101
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:2949 → 3101
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:277 → 324
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:563 → 609
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:611 → 660
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:698 → 757
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1004 → 1116
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:1158 → 1204
      FYRN; F/Y-rich N-terminus

    8. XM_007124163.4 → XP_007124225.1  histone-lysine N-methyltransferase 2A isoform X8

      UniProtKB/TrEMBL
      A0A2Y9FIP7
      Conserved Domains (11) summary
      cd05493
      Location:672 → 802
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:2693 → 2776
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:2855 → 2975
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:2977 → 2993
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:2841 → 2993
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:169 → 216
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:455 → 501
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:503 → 552
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:590 → 649
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:896 → 1008
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:1050 → 1096
      FYRN; F/Y-rich N-terminus
    Nucleotide Protein
    Heading Accession and Version

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