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    Pwp1 PWP1 homolog, endonuclein [ Mus musculus (house mouse) ]

    Gene ID: 103136, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pwp1provided by MGI
    Official Full Name
    PWP1 homolog, endonucleinprovided by MGI
    Primary source
    MGI:MGI:1914735
    See related
    Ensembl:ENSMUSG00000001785 AllianceGenome:MGI:1914735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310058A11Rik; 2610205J09Rik
    Summary
    Enables H4K20me3 modified histone binding activity and histone chaperone activity. Acts upstream of or within negative regulation of peptidyl-serine phosphorylation of STAT protein and positive regulation of stem cell differentiation. Located in nucleus. Is expressed in several structures, including brain; neural retina; and trachea. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 17.4), CNS E18 (RPKM 12.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pwp1 in Genome Data Viewer
    Location:
    10 C1; 10 41.73 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (85707695..85724967)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (85871831..85889103)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 1559 Neighboring gene predicted gene 6721 Neighboring gene uncharacterized protein C12orf73 homolog Neighboring gene PR domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E723 Neighboring gene achaete-scute family bHLH transcription factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables H4K20me3 modified histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone chaperone activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    periodic tryptophan protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133993.3NP_598754.2  periodic tryptophan protein 1 homolog

      See identical proteins and their annotated locations for NP_598754.2

      Status: VALIDATED

      Source sequence(s)
      AK082158, BB032128, BY771053
      Consensus CDS
      CCDS24092.1
      UniProtKB/Swiss-Prot
      Q99LL5, Q9D6T6
      Related
      ENSMUSP00000001836.3, ENSMUST00000001836.11
      Conserved Domains (3) summary
      COG2319
      Location:252493
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:258295
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:252413
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      85707695..85724967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)