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    ZNF211 zinc finger protein 211 [ Homo sapiens (human) ]

    Gene ID: 10520, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF211provided by HGNC
    Official Full Name
    zinc finger protein 211provided by HGNC
    Primary source
    HGNC:HGNC:13003
    See related
    Ensembl:ENSG00000121417 MIM:601856; AllianceGenome:HGNC:13003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF-25; C2H2-25; CH2H2-25
    Summary
    This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in bone marrow (RPKM 5.3), thyroid (RPKM 4.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF211 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57633168..57644041)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60730097..60740970)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58144536..58155409)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15149 Neighboring gene zinc finger protein 530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11077 Neighboring gene zinc finger protein 134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11078 Neighboring gene MPRA-validated peak3574 silencer Neighboring gene zinc finger and SCAN domain containing 4 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58193037-58193660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11079 Neighboring gene zinc finger protein 551

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. Becker KG, et al. Hum Mol Genet, 1995 Apr. PMID 7633419
    2. Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc finger. Becker KG, et al. Mamm Genome, 1997 Apr. PMID 9096115
    3. OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Li J, et al. Theranostics, 2019. PMID 30662561, Free PMC Article
    4. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article
    5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 211
    Names
    zinc finger protein C2H2-25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034028.1 RefSeqGene

      Range
      5002..15875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001265597.3 → NP_001252526.1  zinc finger protein 211 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
      Source sequence(s)
      AC003682, AK294869, AL559417, BQ678885, DA961612, DR002950
      Consensus CDS
      CCDS58686.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000299871.5, ENST00000299871.9
      Conserved Domains (6) summary
      smart00349
      Location:46 → 106
      KRAB; krueppel associated box
      COG5048
      Location:244 → 615
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518 → 540
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:46 → 85
      KRAB; KRAB box
      pfam13465
      Location:420 → 445
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001265598.3 → NP_001252527.1  zinc finger protein 211 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
      Source sequence(s)
      AC003682, AK294869, BQ678885, DA961612, DR002950
      Consensus CDS
      CCDS74468.1
      UniProtKB/TrEMBL
      A0A0A0MTK1
      Related
      ENSP00000442601.2, ENST00000541801.5
      Conserved Domains (6) summary
      smart00349
      Location:33 → 93
      KRAB; krueppel associated box
      COG5048
      Location:231 → 602
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:505 → 527
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:33 → 72
      KRAB; KRAB box
      pfam13465
      Location:407 → 432
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001265599.3 → NP_001252528.1  zinc finger protein 211 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC003682, AK294869, AK296942, BQ678885, DA961612
      Consensus CDS
      CCDS58687.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000254182.7, ENST00000254182.11
      Conserved Domains (4) summary
      COG5048
      Location:170 → 541
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:444 → 466
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:346 → 371
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001265600.3 → NP_001252529.1  zinc finger protein 211 isoform 6

      See identical proteins and their annotated locations for NP_001252529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC003682, AK294869, AK304666, BQ678885, DA961612
      Consensus CDS
      CCDS58688.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000375584.3, ENST00000391703.3
      Conserved Domains (4) summary
      COG5048
      Location:234 → 489
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:392 → 414
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:294 → 319
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001322306.2 → NP_001309235.1  zinc finger protein 211 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC003682, BQ678885, DA961612
      Conserved Domains (4) summary
      COG5048
      Location:242 → 613
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:518 → 538
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:516 → 538
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:418 → 443
      zf-H2C2_2; Zinc-finger double domain

    6. NM_006385.5 → NP_006376.2  zinc finger protein 211 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC003682, AK294869, BQ678885, DA745028, DA961612
      Consensus CDS
      CCDS12956.1
      UniProtKB/Swiss-Prot
      Q13398
      Related
      ENSP00000240731.4, ENST00000240731.5
      Conserved Domains (6) summary
      smart00349
      Location:46 → 87
      KRAB; krueppel associated box
      COG5048
      Location:192 → 563
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:468 → 488
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:466 → 488
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:46 → 85
      KRAB; KRAB box
      pfam13465
      Location:368 → 393
      zf-H2C2_2; Zinc-finger double domain

    7. NM_198855.4 → NP_942152.1  zinc finger protein 211 isoform 2

      See identical proteins and their annotated locations for NP_942152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC003682, AK294869, AK304666, BC034351, BQ678885, DA961612
      Consensus CDS
      CCDS12957.1
      UniProtKB/Swiss-Prot
      B4DH10, B4DLC9, B4E3C9, B9ZVS7, B9ZVW1, F8WDV2, Q05BQ7, Q13398, Q2TAL7, Q59EG4, Q59G36, Q5EBL6
      Related
      ENSP00000339562.3, ENST00000347302.7
      Conserved Domains (6) summary
      smart00349
      Location:33 → 74
      KRAB; krueppel associated box
      COG5048
      Location:179 → 550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:455 → 475
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:453 → 475
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:33 → 72
      KRAB; KRAB box
      pfam13465
      Location:355 → 380
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_049752.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003682, AK294869, BC018138, BQ678885, DA961612

    2. NR_049753.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003682, AK294869, BC110856, BQ678885, DA961612

    3. NR_049754.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC003682, AK294869, AK297047, BQ678885, DA961612

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      57633168..57644041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      60730097..60740970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001290231.1: Suppressed sequence

      Description
      NM_001290231.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13398.2 GenPept UniProtKB/Swiss-Prot:Q13398

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