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    ACTN4 actinin alpha 4 [ Cercocebus atys (sooty mangabey) ]

    Gene ID: 105594457, updated on 13-Mar-2024

    Summary

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    Gene symbol
    ACTN4
    Gene description
    actinin alpha 4
    See related
    Ensembl:ENSCATG00000029753
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cercocebus atys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
    Orthologs
    human mouse all
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    Genomic context

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    See ACTN4 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_011999145.1 (998186..1082541, complement)

    NW_011999145.1Genomic Context describing neighboring genes Neighboring gene galectin 7B Neighboring gene galectin-7 Neighboring gene calpain 12 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_011999145.1 Unplaced Scaffold Reference Caty_1.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-actinin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Caty_1.0

    Genomic

    1. NW_011999145.1 Reference Caty_1.0

      Range
      998186..1082541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012078564.1 → XP_011933954.1  alpha-actinin-4 isoform X4

      See identical proteins and their annotated locations for XP_011933954.1

      UniProtKB/TrEMBL
      A0A2K5LES5, A0A2K5LF87
      Related
      ENSCATP00000011392.1, ENSCATT00000035514.1
      Conserved Domains (5) summary
      COG5126
      Location:762 → 866
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:836 → 902
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:47 → 151
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:155 → 269
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    2. XM_012078546.1 → XP_011933936.1  alpha-actinin-4 isoform X2

      See identical proteins and their annotated locations for XP_011933936.1

      UniProtKB/TrEMBL
      A0A2K5LEK4, A0A2K5LF87
      Related
      ENSCATP00000011386.1, ENSCATT00000035508.1
      Conserved Domains (5) summary
      PTZ00184
      Location:759 → 868
      PTZ00184; calmodulin; Provisional
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:841 → 907
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:47 → 151
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:155 → 269
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    3. XM_012078553.1 → XP_011933943.1  alpha-actinin-4 isoform X3

      See identical proteins and their annotated locations for XP_011933943.1

      UniProtKB/TrEMBL
      A0A2K5LF87
      Conserved Domains (5) summary
      COG5126
      Location:762 → 866
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:836 → 902
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:47 → 151
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:155 → 269
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    4. XM_012078536.1 → XP_011933926.1  alpha-actinin-4 isoform X1

      See identical proteins and their annotated locations for XP_011933926.1

      UniProtKB/TrEMBL
      A0A2K5LEJ8, A0A2K5LF87
      Related
      ENSCATP00000011373.1, ENSCATT00000035495.1
      Conserved Domains (5) summary
      PTZ00184
      Location:759 → 868
      PTZ00184; calmodulin; Provisional
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:841 → 907
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:47 → 151
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:155 → 269
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

    5. XM_012078573.1 → XP_011933963.1  alpha-actinin-4 isoform X5

      See identical proteins and their annotated locations for XP_011933963.1

      UniProtKB/TrEMBL
      A0A2K5LF87
      Related
      ENSCATP00000011557.1, ENSCATT00000035682.1
      Conserved Domains (5) summary
      PTZ00184
      Location:759 → 890
      PTZ00184; calmodulin; Provisional
      cd00176
      Location:414 → 640
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam08726
      Location:863 → 929
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cd21214
      Location:47 → 151
      CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
      cd21216
      Location:155 → 269
      CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
    Nucleotide Protein
    Heading Accession and Version

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