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    DGKA diacylglycerol kinase alpha [ Thamnophis sirtalis ]

    Gene ID: 106539740, updated on 18-Sep-2024

    Summary

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    Gene symbol
    DGKA
    Gene description
    diacylglycerol kinase alpha
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Thamnophis sirtalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis
    Orthologs
    human mouse all
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    Genomic context

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    See DGKA in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    100 current Thamnophis_sirtalis-6.0 (GCF_001077635.1) Unplaced Scaffold NW_013657922.1 (987070..1072481, complement)

    NW_013657922.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_013657922.1 Unplaced Scaffold Reference Thamnophis_sirtalis-6.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Thamnophis sirtalis Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Thamnophis_sirtalis-6.0

    Genomic

    1. NW_013657922.1 Reference Thamnophis_sirtalis-6.0

      Range
      987070..1072481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014054609.1 → XP_013910084.1  diacylglycerol kinase alpha

      UniProtKB/TrEMBL
      A0A6I9Y030
      Conserved Domains (8) summary
      smart00045
      Location:524 → 705
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:382 → 503
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:382 → 715
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:209 → 258
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:117 → 186
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:274 → 326
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:118 → 182
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 113
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_014054611.1 → XP_013910086.1  diacylglycerol kinase alpha

      UniProtKB/TrEMBL
      A0A6I9Y030
      Conserved Domains (8) summary
      smart00045
      Location:524 → 705
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:382 → 503
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:382 → 715
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:209 → 258
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:117 → 186
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:274 → 326
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:118 → 182
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 113
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    3. XM_014054610.1 → XP_013910085.1  diacylglycerol kinase alpha

      UniProtKB/TrEMBL
      A0A6I9Y030
      Conserved Domains (8) summary
      smart00045
      Location:524 → 705
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:382 → 503
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:382 → 715
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:209 → 258
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:117 → 186
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:274 → 326
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:118 → 182
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6 → 113
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    Nucleotide Protein
    Heading Accession and Version

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