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    Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 110893, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc8a3provided by MGI
    Official Full Name
    solute carrier family 8 (sodium/calcium exchanger), member 3provided by MGI
    Primary source
    MGI:MGI:107976
    See related
    Ensembl:ENSMUSG00000079055 AllianceGenome:MGI:107976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ncx3
    Summary
    Enables calcium:sodium antiporter activity. Involved in several processes, including learning or memory; monoatomic cation transmembrane transport; and nervous system development. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; modulation of chemical synaptic transmission; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including mitochondrial outer membrane; postsynaptic density; and sarcolemma. Is expressed in several structures, including bone; brain; foregut; genitourinary system; and trachea. Orthologous to human SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 2.9), frontal lobe adult (RPKM 2.1) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc8a3 in Genome Data Viewer
    Location:
    12 D1; 12 37.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81244686..81380506, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81197915..81333732, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene SPARC related modular calcium binding 1 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_32668 Neighboring gene microRNA 3067 Neighboring gene predicted gene 3693 Neighboring gene STARR-seq mESC enhancer starr_32669 Neighboring gene STARR-seq mESC enhancer starr_32670 Neighboring gene predicted gene, 53730 Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene cytochrome c oxidase assembly protein 16 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC90626

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in calcium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within metal ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within modulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of skeletal muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/calcium exchanger 3
    Names
    Na(+)/Ca(2+)-exchange protein 3
    solute carrier family 8 member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167920.1NP_001161392.1  sodium/calcium exchanger 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001161392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AK044636, AK139260, BC080862
      Consensus CDS
      CCDS49103.1
      UniProtKB/TrEMBL
      Q3UTP5
      Related
      ENSMUSP00000082334.6, ENSMUST00000085238.13
      Conserved Domains (1) summary
      TIGR00845
      Location:1921
      caca; sodium/calcium exchanger 1
    2. NM_001422654.1NP_001409583.1  sodium/calcium exchanger 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124384
    3. NM_080440.3NP_536688.2  sodium/calcium exchanger 3 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains 2 alternate in-frame coding exons compared to variant 1. This results in a slightly longer isoform (2) containing two protein segments not found in isoform 1.
      Source sequence(s)
      AF453257, AK044636, AK139260, BC080862
      Consensus CDS
      CCDS36485.1
      UniProtKB/Swiss-Prot
      Q7TS90, Q8VHJ8, S4R2P9
      UniProtKB/TrEMBL
      Q3UTP5
      Related
      ENSMUSP00000138735.2, ENSMUST00000182208.8
      Conserved Domains (1) summary
      TIGR00845
      Location:1928
      caca; sodium/calcium exchanger 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81244686..81380506 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157165.1XP_036013058.1  sodium/calcium exchanger 3 isoform X1

      UniProtKB/Swiss-Prot
      Q7TS90, Q8VHJ8, S4R2P9
      UniProtKB/TrEMBL
      Q3UTP5
      Conserved Domains (1) summary
      TIGR00845
      Location:1928
      caca; sodium/calcium exchanger 1
    2. XM_006515411.5XP_006515474.1  sodium/calcium exchanger 3 isoform X2

      See identical proteins and their annotated locations for XP_006515474.1

      UniProtKB/TrEMBL
      E9PX50, Q3UTP5
      Related
      ENSMUSP00000063258.8, ENSMUST00000064594.14
      Conserved Domains (1) summary
      TIGR00845
      Location:1927
      caca; sodium/calcium exchanger 1
    3. XM_030246527.1XP_030102387.1  sodium/calcium exchanger 3 isoform X6

      Conserved Domains (1) summary
      TIGR00845
      Location:10298
      caca; sodium/calcium exchanger 1
    4. XM_006515414.4XP_006515477.1  sodium/calcium exchanger 3 isoform X5

      Conserved Domains (1) summary
      TIGR00845
      Location:1304
      caca; sodium/calcium exchanger 1
    5. XM_036157167.1XP_036013060.1  sodium/calcium exchanger 3 isoform X4

      UniProtKB/TrEMBL
      Q9EPU8
      Conserved Domains (1) summary
      TIGR00845
      Location:1601
      caca; sodium/calcium exchanger 1

    RNA

    1. XR_004937405.1 RNA Sequence