CHN2 chimerin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CHN2provided by HGNC
Official Full Name: chimerin 2provided by HGNC
Primary source: HGNC:HGNC:1944
See related: Ensembl:ENSG00000106069 MIM:602857; AllianceGenome:HGNC:1944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BCH; CHN2-3; ARHGAP3; RHOGAP3
Summary: This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Broad expression in duodenum (RPKM 21.4), small intestine (RPKM 16.7) and 20 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7p14.3

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (29146591..29514328)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (29284405..29652211)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (29186207..29553944)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prenatal phthalate exposure and cord blood DNA methylation.
Title: Prenatal phthalate exposure and cord blood DNA methylation.
Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging.
Title: Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging.
The findings indicate that differential methylation at CpG sites upstream of the CHN2 and JAK2 TSS regions are possible peripheral predictors of antidepressant treatment response.
Title: Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.
our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.
Title: A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
this study shows that serum chemerin is an independent risk factor of prognosis of non-small cell lung cancer patients
Title: Prognostic significance of serum chemerin levels in patients with non-small cell lung cancer.
CHN2 is consistently hypermethylated and downregulated in small bowel adenocarcinoma with diagnostic potential
Title: Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility.
CHN2, ABCB1 and PPP1R9A expression on chromosome 7 is implicated in the pathogenesis of hepatosplenic T-cell lymphoma distinguishing it from other malignancies.
Title: Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma.
genetic association studies in a population in Taiwan: Data suggest that an SNP in CHN2 (rs1002630) is associated with non-proliferative diabetic retinopathy in patients with diabetes type 2 in the Han Chinese population studied.
Title: Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.
A significant association of the novel rs186911567 polymorphism was found for the CHN2 gene with smoking.
Title: Association of a novel polymorphism of the β2-chimaerin gene (CHN2) with smoking.
genetic association studies in a Chinese population with type 2 diabetes: An SNP in CHN2 (rs39059) is associated with diabetic retinopathy in a Chinese population of type 2 diabetic patients.
Title: CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of atypical psychosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

SHGC-32133 (e-PCR)
- UniSTS:74760

GDB:1317316 (e-PCR)
- UniSTS:78351

D7S2007 (e-PCR)
- UniSTS:61981

RH18025 (e-PCR)
- UniSTS:72234

RH70289 (e-PCR)
- UniSTS:53034

A006G33 (e-PCR)
- UniSTS:43053

D8S2279 (e-PCR)
- UniSTS:473907

D7S1806 (e-PCR), detects polymorphism
- UniSTS:65595

SHGC-86315 (e-PCR)
- UniSTS:104518

RH12474 (e-PCR)
- UniSTS:57686

L18426 (e-PCR)
- UniSTS:34648

D7S2148E (e-PCR)
- UniSTS:151143

GDB:1317330 (e-PCR)
- UniSTS:3437

G42164 (e-PCR)
- UniSTS:93293

SHGC-78749 (e-PCR)
- UniSTS:95603

G69451 (e-PCR)
- UniSTS:229517

D7S617 (e-PCR)
- UniSTS:54673

D7S435 (e-PCR), detects polymorphism
- UniSTS:76188

D7S1981 (e-PCR)
- UniSTS:11423

D7S1869 (e-PCR)
- UniSTS:45999

D7S1406 (e-PCR)
- UniSTS:41401

D7S2403 (e-PCR)
- UniSTS:22458

D7S617 (e-PCR)
- UniSTS:80842

G32348 (e-PCR)
- UniSTS:116939

SHGC-58598 (e-PCR)
- UniSTS:94417

SHGC-83344 (e-PCR)
- UniSTS:95990

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	TAS Traceable Author Statement more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acrosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: beta-chimaerin

Names: beta-chimerin; beta3-chimaerin; chimerin (chimaerin) 2; chimerin, beta-2; chimerin, testis-specific; rho-GTPase-activating protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029365.3 RefSeqGene

Range

53186..372739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001039936.3 → NP_001035025.1 beta-chimaerin isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform (1).

Source sequence(s)

AC007255

Consensus CDS

CCDS47566.1

UniProtKB/TrEMBL

B7Z701

Related

ENSP00000486515.1, ENST00000412711.7

Conserved Domains (2) summary

cd04372
Location:139 → 332

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:79 → 131

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001293070.2 → NP_001279999.1 beta-chimaerin isoform 4

See identical proteins and their annotated locations for NP_001279999.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AC004417, AC004593, AC007255

Consensus CDS

CCDS94072.1

UniProtKB/TrEMBL

B7Z1V0, B8ZZU1, H7C0V3

Related

ENSP00000386968.2, ENST00000409350.6

Conserved Domains (3) summary

cd10352
Location:65 → 151

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:288 → 481

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:223 → 283

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
NM_001293071.2 → NP_001280000.1 beta-chimaerin isoform 5

See identical proteins and their annotated locations for NP_001280000.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as B2-CHNdel ex3) differs in the 5' UTR and and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AC004417, AC004593, AC007255

UniProtKB/TrEMBL

H7C0V3

Conserved Domains (3) summary

cd10352
Location:17 → 103

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:240 → 433

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:180 → 232

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001293072.2 → NP_001280001.1 beta-chimaerin isoform 6

See identical proteins and their annotated locations for NP_001280001.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (6) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AC004417, AC004593, AC007255

UniProtKB/TrEMBL

B7Z1W9, H7C0V3

Conserved Domains (3) summary

cd10352
Location:37 → 123

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:260 → 453

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:200 → 252

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001293073.2 → NP_001280002.1 beta-chimaerin isoform 7

See identical proteins and their annotated locations for NP_001280002.1

Status: REVIEWED

Description

Transcript Variant: This variant (7, also known as B1-CHNdel ex7p) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.

Source sequence(s)

AC007255

Consensus CDS

CCDS94073.1

UniProtKB/TrEMBL

B7Z701

Related

ENSP00000516243.1, ENST00000467441.6

Conserved Domains (2) summary

cd04372
Location:94 → 287

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:37 → 86

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001293075.2 → NP_001280004.1 beta-chimaerin isoform 8

See identical proteins and their annotated locations for NP_001280004.1

Status: REVIEWED

Description

Transcript Variant: This variant (8, also known as B1-CHNdel ex7p,11) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.

Source sequence(s)

AC007255

UniProtKB/TrEMBL

B7Z701

Conserved Domains (2) summary

pfam00130
Location:37 → 86

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:94 → 241

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001293076.2 → NP_001280005.1 beta-chimaerin isoform 9

See identical proteins and their annotated locations for NP_001280005.1

Status: REVIEWED

Description

Transcript Variant: This variant (9, also known as B1-CHNdel ex9) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (9) is shorter than isoform 1.

Source sequence(s)

AC007255

Consensus CDS

CCDS78219.1

UniProtKB/Swiss-Prot

P52757

Related

ENSP00000394284.2, ENST00000421775.6

Conserved Domains (2) summary

pfam00130
Location:79 → 110

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:107 → 274

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001293077.2 → NP_001280006.1 beta-chimaerin isoform 10

See identical proteins and their annotated locations for NP_001280006.1

Status: REVIEWED

Description

Transcript Variant: This variant (10, also known as B1-CHNdel ex10-11) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (10) is shorter than isoform 1.

Source sequence(s)

AC007255

Consensus CDS

CCDS78218.1

UniProtKB/TrEMBL

B3VCF5

Related

ENSP00000386849.5, ENST00000409041.8

Conserved Domains (2) summary

pfam00130
Location:79 → 131

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:139 → 260

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001293078.2 → NP_001280007.1 beta-chimaerin isoform 11

See identical proteins and their annotated locations for NP_001280007.1

Status: REVIEWED

Description

Transcript Variant: This variant (11, also known as B1-CHNdel ex9,11) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (11) is shorter than isoform 1.

Source sequence(s)

AC007255

Consensus CDS

CCDS78220.1

UniProtKB/TrEMBL

B3VCF4

Related

ENSP00000406337.3, ENST00000424025.5

Conserved Domains (2) summary

pfam00130
Location:79 → 110

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:107 → 228

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001293079.2 → NP_001280008.1 beta-chimaerin isoform 12

See identical proteins and their annotated locations for NP_001280008.1

Status: REVIEWED

Description

Transcript Variant: This variant (12, also known as B1-CHNdel ex11-12) lacks two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (12) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC007255

Consensus CDS

CCDS78217.1

UniProtKB/TrEMBL

B3VCF6

Related

ENSP00000387425.3, ENST00000439711.7

Conserved Domains (2) summary

pfam00130
Location:79 → 131

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:139 → 194

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001293080.2 → NP_001280009.1 beta-chimaerin isoform 13

See identical proteins and their annotated locations for NP_001280009.1

Status: REVIEWED

Description

Transcript Variant: This variant (13, also known as B1-CHNdel ex11) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (13) is shorter than isoform 1.

Source sequence(s)

AC007255

UniProtKB/TrEMBL

B7Z701

Conserved Domains (2) summary

pfam00130
Location:79 → 131

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

cl02570
Location:139 → 286

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001293081.2 → NP_001280010.1 beta-chimaerin isoform 14

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (14) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC007255

UniProtKB/TrEMBL

B7Z215

Conserved Domains (2) summary

cd04372
Location:68 → 261

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:12 → 60

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001398427.1 → NP_001385356.1 beta-chimaerin isoform 15

Status: REVIEWED

Source sequence(s)

AC004417, AC005232, AC007255

Conserved Domains (2) summary

cd04372
Location:129 → 322

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:64 → 124

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
NM_004067.4 → NP_004058.1 beta-chimaerin isoform 2

See identical proteins and their annotated locations for NP_004058.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and contains multiple additional 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation from an alternate start codon. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.

Source sequence(s)

AC004417, AC004593, AC007255

Consensus CDS

CCDS5420.1

UniProtKB/Swiss-Prot

A4D1A2, B3VCF1, B3VCF2, B3VCF3, B3VCF7, B3VCG1, C9J7B0, E9PGE0, F8QPL9, P52757, Q2M203, Q75MM2

UniProtKB/TrEMBL

A0A2X0TVW3, H7C0V3

Related

ENSP00000222792.7, ENST00000222792.11

Conserved Domains (3) summary

cd10352
Location:52 → 138

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:275 → 468

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:210 → 270

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

RNA

NR_120524.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007255
NR_120525.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007255

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

29146591..29514328

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515105.3 → XP_011513407.2 beta-chimaerin isoform X1
XM_011515106.3 → XP_011513408.2 beta-chimaerin isoform X1
XM_017011722.2 → XP_016867211.1 beta-chimaerin isoform X2

UniProtKB/TrEMBL

H7C0V3
XM_011515107.3 → XP_011513409.1 beta-chimaerin isoform X3

UniProtKB/TrEMBL

A0A994J7L4, H7C0V3

Related

ENSP00000516239.1, ENST00000706161.1

Conserved Domains (3) summary

cd10352
Location:78 → 164

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:301 → 494

RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...

pfam00130
Location:241 → 293

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
XM_047419839.1 → XP_047275795.1 beta-chimaerin isoform X4
XM_047419840.1 → XP_047275796.1 beta-chimaerin isoform X1
XM_047419841.1 → XP_047275797.1 beta-chimaerin isoform X1
XM_047419842.1 → XP_047275798.1 beta-chimaerin isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

29284405..29652211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357169.1 → XP_054213144.1 beta-chimaerin isoform X1
XM_054357170.1 → XP_054213145.1 beta-chimaerin isoform X1
XM_054357172.1 → XP_054213147.1 beta-chimaerin isoform X2
XM_054357173.1 → XP_054213148.1 beta-chimaerin isoform X3

UniProtKB/TrEMBL

A0A994J7L4
XM_054357171.1 → XP_054213146.1 beta-chimaerin isoform X4
XM_054357174.1 → XP_054213149.1 beta-chimaerin isoform X1
XM_054357175.1 → XP_054213150.1 beta-chimaerin isoform X1
XM_054357176.1 → XP_054213151.1 beta-chimaerin isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001293069.1: Suppressed sequence

Description

NM_001293069.1: This RefSeq was removed because currently there is insufficient support for the protein.
NR_120523.1: Suppressed sequence

Description

NR_120523.1: This RefSeq was removed because currently there is insufficient support for the transcript.