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    CHP1 calcineurin like EF-hand protein 1 [ Homo sapiens (human) ]

    Gene ID: 11261, updated on 27-Nov-2024

    Summary

    Official Symbol
    CHP1provided by HGNC
    Official Full Name
    calcineurin like EF-hand protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17433
    See related
    Ensembl:ENSG00000187446 MIM:606988; AllianceGenome:HGNC:17433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHP; p22; p24; SPAX9; Sid470p; SLC9A1BP
    Summary
    This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 59.2), liver (RPKM 56.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CHP1 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41231268..41281887)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39037454..39088066)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41523466..41574085)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene CIBAR1 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr15:41472354-41472904 Neighboring gene RNA, 7SL, cytoplasmic 497, pseudogene Neighboring gene exonuclease 3'-5' domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9278 Neighboring gene MPRA-validated peak2306 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41575083-41575824 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:41577309-41578048 Neighboring gene OIP5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9279 Neighboring gene Opa interacting protein 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41628937-41629558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41629559-41630180 Neighboring gene nucleolar and spindle associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Spastic ataxia 9, autosomal recessive
    MedGen: C5193100 OMIM: 618438 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20350

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables potassium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to acidic pH ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic microtubule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane docking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane docking ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of calcineurin-NFAT signaling cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of intracellular pH IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transporter complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcineurin B homologous protein 1
    Names
    EF-hand calcium-binding domain-containing protein p22
    SLC9A1 binding protein
    calcineurin B homolog
    calcineurin B-like protein
    calcineurin homologous protein
    calcium binding protein P22
    calcium-binding protein CHP
    calcium-binding protein p22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007236.5NP_009167.1  calcineurin B homologous protein 1

      See identical proteins and their annotated locations for NP_009167.1

      Status: REVIEWED

      Source sequence(s)
      AC012652
      Consensus CDS
      CCDS10073.1
      UniProtKB/Swiss-Prot
      B2R6H9, Q6FHZ9, Q99653
      Related
      ENSP00000335632.5, ENST00000334660.10
      Conserved Domains (1) summary
      COG5126
      Location:1182
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      41231268..41281887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432125.1XP_047288081.1  calcineurin B homologous protein 1 isoform X2

    2. XM_017021879.3XP_016877368.1  calcineurin B homologous protein 1 isoform X1

      UniProtKB/TrEMBL
      F5GX29, H0YKE7
      Related
      ENSP00000452772.1, ENST00000560784.5
      Conserved Domains (1) summary
      cl25352
      Location:198
      EFh_PEF; The penta-EF hand (PEF) family
    3. XM_047432124.1XP_047288080.1  calcineurin B homologous protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      39037454..39088066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377227.1XP_054233202.1  calcineurin B homologous protein 1 isoform X2

    2. XM_054377225.1XP_054233200.1  calcineurin B homologous protein 1 isoform X1

      UniProtKB/TrEMBL
      H0YKE7
    3. XM_054377226.1XP_054233201.1  calcineurin B homologous protein 1 isoform X2