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    VAV1 vav guanine nucleotide exchange factor 1 [ Theropithecus gelada (gelada) ]

    Gene ID: 112612520, updated on 15-Mar-2024

    Summary

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    Gene symbol
    VAV1
    Gene description
    vav guanine nucleotide exchange factor 1
    See related
    Ensembl:ENSTGEG00000020447
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Theropithecus gelada
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Theropithecus
    Orthologs
    human mouse all
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    Genomic context

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    See VAV1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    100 current Tgel_1.0 (GCF_003255815.1) 19 NC_037687.1 (6743985..6828998)

    Chromosome 19 - NC_037687.1Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene calponin-2 pseudogene

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037687.1 Chromosome 19 Reference Tgel_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene vav

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Theropithecus gelada Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Tgel_1.0 Primary Assembly

    Genomic

    1. NC_037687.1 Reference Tgel_1.0 Primary Assembly

      Range
      6743985..6828998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025367150.1 → XP_025222935.1  proto-oncogene vav isoform X1

      UniProtKB/TrEMBL
      A0A8D2FLI3, A0A8D2K5N3
      Related
      ENSTGEP00000025467.1, ENSTGET00000030316.1
      Conserved Domains (7) summary
      cd10405
      Location:665 → 767
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:786 → 839
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:596 → 658
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:195 → 371
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:385 → 508
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:516 → 567
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00030
      Location:18 → 102
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    2. XM_025367151.1 → XP_025222936.1  proto-oncogene vav isoform X2

      UniProtKB/TrEMBL
      A0A8D2FLI3, A0A8D2FV54
      Related
      ENSTGEP00000025468.1, ENSTGET00000030317.1
      Conserved Domains (7) summary
      cd10405
      Location:643 → 745
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:764 → 817
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd00160
      Location:195 → 371
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:385 → 508
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:516 → 567
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00030
      Location:18 → 102
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl17036
      Location:596 → 639
      SH3; Src Homology 3 domain superfamily

    3. XM_025367152.1 → XP_025222937.1  proto-oncogene vav isoform X3

      UniProtKB/TrEMBL
      A0A8D2FLI3, A0A8D2FU47
      Related
      ENSTGEP00000025471.1, ENSTGET00000030320.1
      Conserved Domains (7) summary
      cd10405
      Location:633 → 735
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:754 → 807
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:564 → 626
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      smart00325
      Location:187 → 340
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01223
      Location:353 → 476
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:484 → 535
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00030
      Location:18 → 102
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    4. XM_025367154.1 → XP_025222939.1  proto-oncogene vav isoform X5

      UniProtKB/TrEMBL
      A0A8D2FLI3
      Related
      ENSTGEP00000025475.1, ENSTGET00000030324.1
      Conserved Domains (7) summary
      cd10405
      Location:614 → 716
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:735 → 788
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:545 → 607
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:144 → 320
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:334 → 457
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:465 → 516
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00307
      Location:15 → 67
      CH; Calponin homology (CH) domain

    5. XM_025367153.1 → XP_025222938.1  proto-oncogene vav isoform X4

      UniProtKB/TrEMBL
      A0A8D2FLI3
      Conserved Domains (7) summary
      cd10405
      Location:609 → 711
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:730 → 783
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:540 → 602
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:139 → 315
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:329 → 452
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:460 → 511
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00307
      Location:10 → 62
      CH; Calponin homology (CH) domain
    Nucleotide Protein
    Heading Accession and Version

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