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    VAV1 vav guanine nucleotide exchange factor 1 [ Callorhinus ursinus (northern fur seal) ]

    Gene ID: 112815267, updated on 15-Mar-2024

    Summary

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    Gene symbol
    VAV1
    Gene description
    vav guanine nucleotide exchange factor 1
    See related
    EnsemblRapid:ENSCURG00000025888
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Callorhinus ursinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Otariidae; Callorhinus
    Orthologs
    human mouse all
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    Genomic context

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    See VAV1 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    100 current ASM326570v1 (GCF_003265705.1) Unplaced Scaffold NW_020313288.1 (146117..195414, complement)

    NW_020313288.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E4-like Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene SH2 domain containing 3A Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene G protein-coupled receptor 108

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_020313288 Unplaced Scaffold Reference ASM326570v1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene vav

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Callorhinus ursinus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM326570v1 Primary Assembly

    Genomic

    1. NW_020313288.1 Reference ASM326570v1 Primary Assembly

      Range
      146117..195414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025861080.1 → XP_025716865.1  proto-oncogene vav isoform X2

      UniProtKB/TrEMBL
      A0A3Q7N9J2
      Conserved Domains (7) summary
      cd10405
      Location:665 → 767
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:785 → 838
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:596 → 658
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:195 → 371
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:385 → 508
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:516 → 564
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00030
      Location:18 → 102
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    2. XM_025861079.1 → XP_025716864.1  proto-oncogene vav isoform X1

      UniProtKB/TrEMBL
      A0A3Q7NA31
      Related
      ENSCURP00000042272.1, ENSCURT00000048005.1
      Conserved Domains (7) summary
      cd10405
      Location:665 → 767
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:786 → 839
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:596 → 658
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:195 → 371
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:385 → 508
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:516 → 564
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00030
      Location:18 → 102
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

    3. XM_025861081.1 → XP_025716866.1  proto-oncogene vav isoform X3

      UniProtKB/TrEMBL
      A0A3Q7PLI5
      Conserved Domains (6) summary
      cd10405
      Location:539 → 641
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cd11976
      Location:660 → 713
      SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
      cd11979
      Location:470 → 532
      SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
      cd00160
      Location:69 → 245
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:259 → 382
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00130
      Location:390 → 438
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version

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