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    STK11IP serine/threonine kinase 11 interacting protein [ Homo sapiens (human) ]

    Gene ID: 114790, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STK11IPprovided by HGNC
    Official Full Name
    serine/threonine kinase 11 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:19184
    See related
    Ensembl:ENSG00000144589 MIM:607172; AllianceGenome:HGNC:19184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIP1; LKB1IP; STK11IP1
    Summary
    Enables protein kinase binding activity. Involved in protein localization. Located in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 10.6), spleen (RPKM 4.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK11IP in Genome Data Viewer
    Location:
    2q35
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219597857..219616451)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (220082587..220101184)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220462579..220481173)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220441287-220441862 Neighboring gene inhibin subunit alpha Neighboring gene RN7SK pseudogene 213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17156 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:220469784-220470983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220472989-220473488 Neighboring gene uncharacterized LOC124908064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220492855-220493557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220493558-220494259 Neighboring gene solute carrier family 4 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17157 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220508228-220508999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220509771-220510541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220510542-220511311 Neighboring gene CRISPRi-validated cis-regulatory element chr2.6714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220528008-220528541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:220537307-220537807 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:220548733-220549932 Neighboring gene DNAJB6 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. Tian M, et al. J Cell Mol Med, 2021 Mar. PMID 33486894, Free PMC Article
    2. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Conde E, et al. Hum Pathol, 2007 Sep. PMID 17521700
    3. Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1. Morén A, et al. J Biol Chem, 2011 Jan 7. PMID 20974850, Free PMC Article
    4. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Smith DP, et al. Hum Mol Genet, 2001 Dec 1. PMID 11741830
    5. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. Nagase T, et al. DNA Res, 2001 Aug 31. PMID 11572484

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
      Title: LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
    2. LKB1 and LIP1 provide negative control of TGFbeta signaling.
      Title: Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
    3. observations provide complete information about the pattern and levels of LKB1 & p-acetyl-CoA carboxylase immunostaining in normal tissues and in lung tumors, and highlight the special relevance of abnormalities of the LKB1 pathway in lung adenocarcinoma
      Title: Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1898

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in lysosomal membrane HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 11-interacting protein
    Names
    LKB1-interacting protein 1
    STK11 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052902.4 → NP_443134.3  serine/threonine-protein kinase 11-interacting protein

      Status: VALIDATED

      Source sequence(s)
      AC009955, BC014114, BC034051, HY001118
      Consensus CDS
      CCDS46521.2
      UniProtKB/Swiss-Prot
      C9JQV3, Q8N1F8, Q8NAW9, Q8WXE4, Q96CN3, Q96PY9
      Related
      ENSP00000389383.1, ENST00000456909.6
      Conserved Domains (4) summary
      COG4886
      Location:101 → 301
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:160 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam15904
      Location:4 → 93
      LIP1; LKB1 serine/threonine kinase interacting protein 1
      cl19201
      Location:668 → 719
      HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      219597857..219616451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510526.2 → XP_011508828.1  serine/threonine-protein kinase 11-interacting protein isoform X2

      Conserved Domains (6) summary
      cd00116
      Location:110 → 289
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:160 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:234 → 275
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:236 → 291
      LRR_8; Leucine rich repeat
      pfam15904
      Location:4 → 93
      LIP1; LKB1 serine/threonine kinase interacting protein 1
      cl19201
      Location:668 → 719
      HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

    2. XM_011510527.4 → XP_011508829.1  serine/threonine-protein kinase 11-interacting protein isoform X3

      Conserved Domains (6) summary
      cd00116
      Location:110 → 289
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:160 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:234 → 275
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:236 → 291
      LRR_8; Leucine rich repeat
      pfam15904
      Location:4 → 93
      LIP1; LKB1 serine/threonine kinase interacting protein 1
      cl19201
      Location:668 → 719
      HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

    3. XM_047443102.1 → XP_047299058.1  serine/threonine-protein kinase 11-interacting protein isoform X4

    4. XM_047443104.1 → XP_047299060.1  serine/threonine-protein kinase 11-interacting protein isoform X5

    5. XM_011510529.2 → XP_011508831.1  serine/threonine-protein kinase 11-interacting protein isoform X6

      UniProtKB/TrEMBL
      B4DUE4
      Conserved Domains (5) summary
      cd00116
      Location:110 → 289
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:160 → 187
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:234 → 275
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:236 → 291
      LRR_8; Leucine rich repeat
      pfam15904
      Location:4 → 93
      LIP1; LKB1 serine/threonine kinase interacting protein 1

    6. XM_011510528.3 → XP_011508830.1  serine/threonine-protein kinase 11-interacting protein isoform X1

      Conserved Domains (1) summary
      cl19201
      Location:313 → 364
      HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

    RNA

    1. XR_922834.3 RNA Sequence

    2. XR_922835.3 RNA Sequence

      Related
      ENST00000475396.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      220082587..220101184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340334.1 → XP_054196309.1  serine/threonine-protein kinase 11-interacting protein isoform X7

    2. XM_054340335.1 → XP_054196310.1  serine/threonine-protein kinase 11-interacting protein isoform X8

    3. XM_054340336.1 → XP_054196311.1  serine/threonine-protein kinase 11-interacting protein isoform X9

    4. XM_054340337.1 → XP_054196312.1  serine/threonine-protein kinase 11-interacting protein isoform X10

    5. XM_054340339.1 → XP_054196314.1  serine/threonine-protein kinase 11-interacting protein isoform X11

      UniProtKB/TrEMBL
      B4DUE4

    6. XM_054340338.1 → XP_054196313.1  serine/threonine-protein kinase 11-interacting protein isoform X1

    RNA

    1. XR_008486255.1 RNA Sequence

    2. XR_008486256.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N1F8.4 GenPept UniProtKB/Swiss-Prot:Q8N1F8

    Gene LinkOut

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