Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacnb2provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit beta 2provided by RGD
Primary source: RGD:67385
See related: EnsemblRapid:ENSRNOG00000018378 AllianceGenome:RGD:67385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cacnlb2
Summary: Enables several functions, including actin filament binding activity; calcium channel regulator activity; and identical protein binding activity. Contributes to voltage-gated calcium channel activity. Involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of high voltage-gated calcium channel activity; and protein localization to plasma membrane. Part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 136.8), Thymus (RPKM 126.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (82473097..82818564)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (77564630..77910000)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (81673862..82019219)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2.
Title: Bipolar-associated miR-499-5p controls neuroplasticity by downregulating the Cav1.2 subunit CACNB2.
The expression level of CACNB2 was up-regulated in the high salt (HS) diet fed Dahl Salt-Sensitive (SS) rat kidneys compared to low salt diet (LS) fed group. Similar to our in vitro observation the RAS-MAPK mRNA levels were increased in HS fed SS rat kidneys, compared to LS fed group.
Title: CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats.
these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1.
Title: Homer proteins mediate the interaction between STIM1 and Cav1.2 channels.
Cacnb2 is selectively targeted to the axon terminals of supraoptic neurons.
Title: The Ca2+ channel β2 subunit is selectively targeted to the axon terminals of supraoptic neurons.
a model in which CaVbeta promotes anterograde trafficking of the L-type channels by anchoring them to actin filaments in their itinerary to the plasma membrane.
Title: Direct interaction of CaVβ with actin up-regulates L-type calcium currents in HL-1 cardiomyocytes.
analysis of how voltage-gated calcium channel beta2e-subunit N-terminal domain is tethered to the plasma membrane via electrostatic and hydrophobic interactions
Title: The N-terminal domain tethers the voltage-gated calcium channel β2e-subunit to the plasma membrane via electrostatic and hydrophobic interactions.
Data show that ablation of L-type calcium channels partially blocks Akt inhibition-induced reduction in glucose-stimulated insulin secretion but completely prevents that in potassium depolarization-evoked insulin release from INS-1 cells.
Title: Akt signals upstream of L-type calcium channels to optimize insulin secretion.
Cardiac L-type Ca channel beta2 subunit protein expression may be downregulated by miRs in response to long-term activation of beta-adrenergic signaling, possibly as an adaptive response in cardiac hypertrophy and sustained beta-adrenergic states.
Title: Posttranscriptional regulation of the β2-subunit of cardiac L-type Ca2+ channels by MicroRNAs during long-term exposure to isoproterenol in rats.
Beta subunits play a role in PKA modulation of Ca(V)1.2 channels and uncover a new design principle of this phenomenon in the heart, vis a vis a limited functional reserve.
Title: Role of CaVbeta subunits, and lack of functional reserve, in protein kinase A modulation of cardiac CaV1.2 channels.
This study provides the first evidence to demonstrate that LTCC beta2 subunit is coupled with the movement of signals in the mechanism of activation of NKA-mediated crosstalk with LTCC.
Title: Serine496 of β2 subunit of L-type Ca2+ channel participates in molecular crosstalk between activation of (Na++K+)-ATPase and the channel.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Got99 (e-PCR)
- UniSTS:113452

D17Wox7 (e-PCR)
- UniSTS:118063

BE109990 (e-PCR)
- UniSTS:248386

G15938 (e-PCR)
- UniSTS:79201

BE097150 (e-PCR)
- UniSTS:244608

RH144615 (e-PCR)
- UniSTS:233860

RH129340 (e-PCR)
- UniSTS:212647

RH133733 (e-PCR)
- UniSTS:217016

D17Arb12 (e-PCR)
- UniSTS:240071

RH138021 (e-PCR)
- UniSTS:220108

AU048422 (e-PCR)
- UniSTS:144872

RH138575 (e-PCR)
- UniSTS:220662

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables high voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed
enables voltage-gated calcium channel activity involved in AV node cell action potential	IEA Inferred from Electronic Annotation more info
contributes_to voltage-gated calcium channel activity involved in AV node cell action potential	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated calcium channel activity involved in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
contributes_to voltage-gated calcium channel activity involved in cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during atrial cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of L-type voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in photoreceptor ribbon synapse	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor ribbon synapse	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit beta-2

Names: CAB2; calcium channel voltage-dependent subunit beta 2; calcium channel, voltage-dependent, beta 2 subunit; voltage-gated calcium channel beta2i subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398773.1 → NP_001385702.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6A7Q8, A6JM59

Related

ENSRNOP00000088262.1, ENSRNOT00000101858.2

Conserved Domains (4) summary

cd12040
Location:108 → 176

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

TIGR01622
Location:586 → 643

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:276 → 457

Guanylate_kin; Guanylate kinase

pfam12052
Location:68 → 109

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
NM_053851.2 → NP_446303.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 2

See identical proteins and their annotated locations for NP_446303.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A0G2JSZ0, A0A8I5XWR2, A6JM63

Related

ENSRNOP00000093071.1, ENSRNOT00000118698.2

Conserved Domains (4) summary

cd12040
Location:57 → 125

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

pfam00625
Location:225 → 406

Guanylate_kin; Guanylate kinase

pfam12052
Location:17 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl17190
Location:235 → 407

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

82473097..82818564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095296.2 → XP_038951224.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X1

UniProtKB/Swiss-Prot

Q811Q6, Q811Q7, Q8VGC3, Q91ZJ8, Q9QUU7

Conserved Domains (4) summary

cd12040
Location:108 → 176

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

TIGR01622
Location:585 → 642

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:276 → 456

Guanylate_kin; Guanylate kinase

pfam12052
Location:68 → 109

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_039095297.2 → XP_038951225.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X4

UniProtKB/Swiss-Prot

Q811Q6, Q811Q7, Q8VGC3, Q91ZJ8, Q9QUU7

Conserved Domains (4) summary

cd12040
Location:108 → 176

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

TIGR01622
Location:548 → 605

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:238 → 419

Guanylate_kin; Guanylate kinase

pfam12052
Location:68 → 109

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_039095298.2 → XP_038951226.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X5

UniProtKB/Swiss-Prot

Q811Q6, Q811Q7, Q8VGC3, Q91ZJ8, Q9QUU7

Conserved Domains (4) summary

cd12040
Location:108 → 176

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

TIGR01622
Location:547 → 604

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:238 → 418

Guanylate_kin; Guanylate kinase

pfam12052
Location:68 → 109

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006254298.5 → XP_006254360.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X2

See identical proteins and their annotated locations for XP_006254360.1

UniProtKB/Swiss-Prot

Q811Q6, Q811Q7, Q8VGC3, Q91ZJ8, Q9QUU7

UniProtKB/TrEMBL

A6JM60

Related

ENSRNOP00000093724.2, ENSRNOT00000103017.2

Conserved Domains (4) summary

cd12040
Location:84 → 152

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

pfam00625
Location:252 → 433

Guanylate_kin; Guanylate kinase

pfam12052
Location:44 → 85

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl17190
Location:262 → 434

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_017600435.3 → XP_017455924.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X3

UniProtKB/Swiss-Prot

Q811Q6, Q811Q7, Q8VGC3, Q91ZJ8, Q9QUU7
XM_017600438.3 → XP_017455927.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X10

UniProtKB/Swiss-Prot

Q811Q6, Q811Q7, Q8VGC3, Q91ZJ8, Q9QUU7
XM_039095300.2 → XP_038951228.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X9

UniProtKB/TrEMBL

A0A8I5XWR2

Related

ENSRNOP00000078040.2, ENSRNOT00000113123.2

Conserved Domains (4) summary

cd12040
Location:57 → 125

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

TIGR01622
Location:534 → 591

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:225 → 405

Guanylate_kin; Guanylate kinase

pfam12052
Location:17 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_063276025.1 → XP_063132095.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X14

Related

ENSRNOP00000094678.2, ENSRNOT00000101293.2
XM_063276026.1 → XP_063132096.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X15
XM_039095299.2 → XP_038951227.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X13

UniProtKB/TrEMBL

A0A678X7M6, A0A8I6AEJ4

Conserved Domains (4) summary

cd12040
Location:58 → 126

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

TIGR01622
Location:498 → 555

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:188 → 369

Guanylate_kin; Guanylate kinase

pfam12052
Location:18 → 59

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006254303.5 → XP_006254365.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X8

See identical proteins and their annotated locations for XP_006254365.1

UniProtKB/TrEMBL

A0A8I6GKE9, A6JM66

Related

ENSRNOP00000063474.2, ENSRNOT00000066826.5

Conserved Domains (4) summary

cd12040
Location:58 → 126

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

pfam00625
Location:226 → 407

Guanylate_kin; Guanylate kinase

pfam12052
Location:18 → 59

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl17190
Location:236 → 408

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006254301.5 → XP_006254363.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X6

See identical proteins and their annotated locations for XP_006254363.1

UniProtKB/TrEMBL

A0A8I6AK39, A6JM67, D3ZWK0

Conserved Domains (4) summary

cd12040
Location:64 → 132

SH3_CACNB2; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta2

pfam00625
Location:232 → 413

Guanylate_kin; Guanylate kinase

pfam12052
Location:24 → 65

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

cl17190
Location:242 → 414

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_017600436.3 → XP_017455925.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X7

UniProtKB/TrEMBL

A0A8I6AK39

Related

ENSRNOP00000037354.5, ENSRNOT00000031542.7
XM_063276023.1 → XP_063132093.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X11

UniProtKB/TrEMBL

A6JM68
XM_063276024.1 → XP_063132094.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X12
XM_039095301.2 → XP_038951229.1 voltage-dependent L-type calcium channel subunit beta-2 isoform X16

Conserved Domains (2) summary

TIGR01622
Location:310 → 367

SF-CC1; splicing factor, CC1-like family

pfam00625
Location:1 → 181

Guanylate_kin; Guanylate kinase