U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ube2n ubiquitin-conjugating enzyme E2N [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116725, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2nprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Nprovided by RGD
    Primary source
    RGD:621096
    See related
    EnsemblRapid:ENSRNOG00000073414 AllianceGenome:RGD:621096
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ubiquitin-protein transferase activity. Involved in regulation protein catabolic process at postsynapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human UBE2N (ubiquitin conjugating enzyme E2 N). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 481.8), Brain (RPKM 455.2) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ube2n in Genome Data Viewer
    Location:
    7q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (32041190..32071252)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (30154330..30184373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (36610147..36640190)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene uncharacterized LOC102556774 Neighboring gene nudix hydrolase 4 Neighboring gene uncharacterized LOC102546610

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93937

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of DNA double-strand break processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of postreplication repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of UBC13-MMS2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin conjugating enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 N
    Names
    E2 ubiquitin-conjugating enzyme N
    bendless protein
    bendless-like ubiquitin-conjugating enzyme
    ubiquitin carrier protein N
    ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
    ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
    ubiquitin-protein ligase N
    NP_446380.1
    XP_063118946.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053928.2NP_446380.1  ubiquitin-conjugating enzyme E2 N

      See identical proteins and their annotated locations for NP_446380.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090072
      UniProtKB/Swiss-Prot
      Q9EQX9
      UniProtKB/TrEMBL
      A6IG42
      Related
      ENSRNOP00000108459.1, ENSRNOT00000138953.1
      Conserved Domains (1) summary
      cl00154
      Location:4151
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      32041190..32071252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262876.1XP_063118946.1  ubiquitin-conjugating enzyme E2 N isoform X1