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    NSD3 nuclear receptor binding SET domain protein 3 [ Chelonoidis abingdonii (Abingdon island giant tortoise) ]

    Gene ID: 116821414, updated on 18-Mar-2024

    Summary

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    Gene symbol
    NSD3
    Gene description
    nuclear receptor binding SET domain protein 3
    See related
    Ensembl:ENSCABG00000014276
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Chelonoidis abingdonii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira; Testudinoidea; Testudinidae; Chelonoidis
    Orthologs
    human mouse all
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    Genomic context

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    See NSD3 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    100 current ASM359739v1 (GCF_003597395.1) Unplaced Scaffold NW_022641411.1 (1815813..1880313)

    NW_022641411.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor receptor 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene phospholipid phosphatase 5 Neighboring gene uncharacterized LOC116821419 Neighboring gene DDHD domain containing 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_022641411 Unplaced Scaffold Reference ASM359739v1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K36 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase NSD3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Chelonoidis abingdonii Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM359739v1

    Genomic

    1. NW_022641411.1 Reference ASM359739v1

      Range
      1815813..1880313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_032774589.1 → XP_032630480.1  histone-lysine N-methyltransferase NSD3 isoform X3

      UniProtKB/TrEMBL
      A0A8C0HI42
      Conserved Domains (9) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:961 → 1054
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:920 → 955
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cl40432
      Location:1147 → 1181
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam17907
      Location:1107 → 1145
      AWS; AWS domain

    2. XM_032774591.1 → XP_032630482.1  histone-lysine N-methyltransferase NSD3 isoform X5

      Conserved Domains (7) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:920 → 955
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cl02554
      Location:961 → 986
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    3. XM_032774590.1 → XP_032630481.1  histone-lysine N-methyltransferase NSD3 isoform X4

      Conserved Domains (7) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:920 → 955
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cl02554
      Location:961 → 986
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

    4. XM_032774586.1 → XP_032630477.1  histone-lysine N-methyltransferase NSD3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0HI42
      Conserved Domains (11) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:961 → 1054
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:920 → 955
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:1326 → 1368
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cd19212
      Location:1147 → 1288
      SET_NSD3; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins
      pfam17907
      Location:1107 → 1145
      AWS; AWS domain
      pfam17982
      Location:1367 → 1416
      C5HCH; NSD Cys-His rich domain

    5. XM_032774588.1 → XP_032630479.1  histone-lysine N-methyltransferase NSD3 isoform X2

      UniProtKB/TrEMBL
      A0A8C0HI42
      Conserved Domains (10) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:961 → 1054
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:920 → 955
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:1326 → 1368
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cd19212
      Location:1147 → 1288
      SET_NSD3; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins
      pfam17907
      Location:1107 → 1145
      AWS; AWS domain

    6. XM_032774592.1 → XP_032630483.1  histone-lysine N-methyltransferase NSD3 isoform X6

      Conserved Domains (5) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)

    7. XM_032774594.1 → XP_032630485.1  histone-lysine N-methyltransferase NSD3 isoform X8

      Conserved Domains (5) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)

    8. XM_032774593.1 → XP_032630484.1  histone-lysine N-methyltransferase NSD3 isoform X7

      Conserved Domains (5) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)

    9. XM_032774596.1 → XP_032630487.1  histone-lysine N-methyltransferase NSD3 isoform X9

      Conserved Domains (5) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)

    10. XM_032774587.1 → XP_032630478.1  histone-lysine N-methyltransferase NSD3 isoform X1

      UniProtKB/TrEMBL
      A0A8C0HI42
      Related
      ENSCABP00000019846.1, ENSCABT00000021745.1
      Conserved Domains (11) summary
      cd05837
      Location:267 → 384
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      cd05838
      Location:961 → 1054
      WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
      COG5034
      Location:615 → 748
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15649
      Location:705 → 748
      PHD1_NSD3; PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15652
      Location:753 → 799
      PHD2_NSD3; PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15655
      Location:800 → 852
      PHD3_NSD3; PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15658
      Location:920 → 955
      PHD4_NSD3; PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3)
      cd15661
      Location:1326 → 1368
      PHD5_NSD3; PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3)
      cd19212
      Location:1147 → 1288
      SET_NSD3; SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins
      pfam17907
      Location:1107 → 1145
      AWS; AWS domain
      pfam17982
      Location:1367 → 1416
      C5HCH; NSD Cys-His rich domain
    Nucleotide Protein
    Heading Accession and Version

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