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    iqgap2 IQ motif containing GTPase activating protein 2 [ Pimephales promelas (fathead minnow) ]

    Gene ID: 120461792, updated on 21-Mar-2024

    Summary

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    Gene symbol
    iqgap2
    Gene description
    IQ motif containing GTPase activating protein 2
    Locus tag
    F2P79_018147
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pimephales promelas
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Leuciscidae; Pogonichthyinae; Pimephales
    Orthologs
    human zebrafish all
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    Genomic context

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    See iqgap2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    100 current EPA_FHM_2.0 (GCF_016745375.1) Unplaced Scaffold NW_024121577.1 (304670..367959)

    NW_024121577.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene POC5 centriolar protein homolog (Chlamydomonas) Neighboring gene synaptic vesicle glycoprotein 2Ca Neighboring gene coagulation factor II (thrombin) receptor-like 2 Neighboring gene uncharacterized LOC120461824 Neighboring gene coagulation factor II (thrombin) receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024121577 Unplaced Scaffold Reference EPA_FHM_2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras GTPase-activating-like protein IQGAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Pimephales promelas Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EPA_FHM_2.0 Primary Assembly

    Genomic

    1. NW_024121577.1 Reference EPA_FHM_2.0 Primary Assembly

      Range
      304670..367959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039650079.1 → XP_039506013.1  ras GTPase-activating-like protein IQGAP2 isoform X2

      Conserved Domains (4) summary
      cd05131
      Location:1002 → 1360
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5022
      Location:747 → 922
      COG5022; Myosin heavy chain [General function prediction only]
      COG5261
      Location:845 → 1611
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cd00201
      Location:683 → 711
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    2. XM_039650080.1 → XP_039506014.1  ras GTPase-activating-like protein IQGAP2 isoform X3

      Conserved Domains (5) summary
      cd05131
      Location:1002 → 1360
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5022
      Location:747 → 922
      COG5022; Myosin heavy chain [General function prediction only]
      COG5261
      Location:845 → 1663
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cd00201
      Location:683 → 711
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd21275
      Location:11 → 166
      CH_IQGAP2; calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP2

    3. XM_039650078.1 → XP_039506012.1  ras GTPase-activating-like protein IQGAP2 isoform X1

      Conserved Domains (5) summary
      cd05131
      Location:1002 → 1360
      RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
      COG5022
      Location:747 → 922
      COG5022; Myosin heavy chain [General function prediction only]
      COG5261
      Location:845 → 1663
      IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
      cd00201
      Location:683 → 711
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd21275
      Location:11 → 166
      CH_IQGAP2; calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP2
    Nucleotide Protein
    Heading Accession and Version

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