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    LOC121865243 gelsolin, cytoplasmic [ Homarus americanus (American lobster) ]

    Gene ID: 121865243, updated on 7-Dec-2023

    Summary

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    Gene symbol
    LOC121865243
    Gene description
    gelsolin, cytoplasmic
    Locus tag
    Hamer_G021872
    See related
    EnsemblRapid:LOC121865243
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Homarus americanus
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea; Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea; Nephropoidea; Nephropidae; Homarus
    Also known as
    ADF; gsn; Gels-L; gelsolin
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    Genomic context

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    See LOC121865243 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    100 current GMGI_Hamer_2.0 (GCF_018991925.1) Unplaced Scaffold NW_024725586.1 (21851..122568, complement)

    NW_024725586.1Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon CGU) Neighboring gene locomotion-related protein Hikaru genki-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024725586 Unplaced Scaffold Reference GMGI_Hamer_2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isoforms of gelsolin from lobster striated muscles differ in calcium-dependence. Unger A, et al. Arch Biochem Biophys, 2013 Aug 1. PMID 23707758
    2. A gelsolin-related protein from lobster muscle: cloning, sequence analysis and expression. Lück A, et al. Biochem J, 1995 Feb 1. PMID 7848275, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament severing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gelsolin, cytoplasmic
    Names
    Actin-depolymerizing factor
    Gelsolin, cytoplasmic-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Homarus americanus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GMGI_Hamer_2.0 Primary Assembly

    Genomic

    1. NW_024725586.1 Reference GMGI_Hamer_2.0 Primary Assembly

      Range
      21851..122568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042364594.1 → XP_042220528.1  gelsolin, cytoplasmic isoform X3

      UniProtKB/TrEMBL
      A0A8J5KKY0
      Related
      XP_042220528.1, XM_042364594.1
      Conserved Domains (6) summary
      cd11288
      Location:525 → 616
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:629 → 728
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 345
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:398 → 498
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    2. XM_042364593.1 → XP_042220527.1  gelsolin, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A0A8J5KKY0
      Related
      XP_042220527.1, XM_042364593.1
      Conserved Domains (6) summary
      cd11288
      Location:529 → 620
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:633 → 732
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 349
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:402 → 502
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    3. XM_042364592.1 → XP_042220526.1  gelsolin, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A0A8J5KKY0
      Related
      XP_042220526.1, XM_042364592.1
      Conserved Domains (6) summary
      cd11288
      Location:529 → 620
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:633 → 732
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 349
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:402 → 502
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    4. XM_042364597.1 → XP_042220531.1  gelsolin, cytoplasmic isoform X6

      UniProtKB/Swiss-Prot
      Q27319
      UniProtKB/TrEMBL
      I7L125
      Related
      XP_042220531.1, XM_042364597.1
      Conserved Domains (6) summary
      cd11288
      Location:525 → 616
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:629 → 728
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 345
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:398 → 498
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    5. XM_042364599.1 → XP_042220533.1  gelsolin, cytoplasmic isoform X8

      UniProtKB/Swiss-Prot
      Q27319
      UniProtKB/TrEMBL
      I7ITS8
      Related
      XP_042220533.1, XM_042364599.1
      Conserved Domains (6) summary
      cd11288
      Location:525 → 616
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:629 → 728
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 345
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:398 → 498
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    6. XM_042364596.1 → XP_042220530.1  gelsolin, cytoplasmic isoform X5

      UniProtKB/Swiss-Prot
      Q27319
      Related
      XP_042220530.1, XM_042364596.1
      Conserved Domains (6) summary
      cd11288
      Location:529 → 620
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:633 → 732
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 349
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:402 → 502
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    7. XM_042364595.1 → XP_042220529.1  gelsolin, cytoplasmic isoform X4

      UniProtKB/Swiss-Prot
      Q27319
      Related
      XP_042220529.1, XM_042364595.1
      Conserved Domains (6) summary
      cd11288
      Location:529 → 620
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:633 → 732
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 349
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:402 → 502
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    8. XM_042364598.1 → XP_042220532.1  gelsolin, cytoplasmic isoform X7

      UniProtKB/Swiss-Prot
      Q27319
      Related
      XP_042220532.1, XM_042364598.1
      Conserved Domains (6) summary
      cd11288
      Location:529 → 620
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:131 → 223
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:5 → 116
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:633 → 732
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247 → 349
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:402 → 502
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27319.1 GenPept UniProtKB/Swiss-Prot:Q27319

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